货号：MAB394-100UG

品牌：Merck Millipore

规格：100Ug

目录价：￥22546.00

市场价格：￥19164.10

会员价格：￥18036.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2 | MAB394-100UG View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Trade Name: Chemicon (Millipore) View All» Specificity: Dopamine b-HydroxylaseDBH is a single gene product that exists as a cytosolic enzyme, as a membrane protein and is secreted into the circulation (Lewis & Asnani, 1992). Because of its residence time as a plasma membrane-bound protein, it is able to be used as a targeting agent for neurons. The target neurons include postganglionic sympathetic neurons and all noradrenergic and adrenergic neurons of the central nervous system. As such anti-DBH-SAP can be used for the production of acute peripheral autonomic failure in a model for the human disease. It can also be used for the analysis of the behavioral effects of noradrenergic or adrenergic ablation. When injected intraventricularly, noradrenergic neurons of the locus coeruleus are eliminated (Wiley & Lappi, 1994). The antibody and immunotoxin undergo retrograde transport. MAB308 is the unconjugated monoclonal. View All» Clone: 4F10.2 View All» Isotype: IgG1 View All» Species Reactivity: Rat View All» Application Notes: Immunotoxin View All» Presentation: Saporin Conjugated. Sterile liquid. Provided in phosphate buffered saline. Contains no preservative. View All» Storage Conditions: The material should be stored at -80°C for up to six months under sterile conditions. Avoid repeated freeze-thaw cycles. View All» UniProt Number: P09172 View All» Entrez Gene Number: NM_000787.3 View All» Gene Symbol:

• DBH

• DBM

• EC 1.14.17.1 [Contains: Soluble dopamine beta-hydroxylase].
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. View All» UniProt Summary: FUNCTION: SwissProt: P09172 # Conversion of dopamine to noradrenaline.COFACTOR: Binds 1 PQQ per subunit. & Binds 2 copper ions per subunit.SIZE: 617 amino acids; 69065 Da SUBUNIT: Homotetramer composed of two non-covalently bound disulfide-linked dimers.SUBCELLULAR LOCATION: Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. & Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single- pass type II membrane protein (Potential).DISEASE: SwissProt: P09172 # Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.SIMILARITY: SwissProt: P09172 ## Belongs to the copper type II ascorbate-dependent monooxygenase family. & Contains 1 DOMON domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2 | MAB394-100UG View All» Concentration: 2.1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Saporin View All» Host: Mouse View All»
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