货号：04-1465

品牌：Merck Millipore

规格：EA

目录价：￥3468.00

市场价格：￥2947.80

会员价格：￥2774.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Gemin2 Antibody, clone 2S7 | 04-1465 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Gemin 2. View All» Molecular Weight: ~ 32 kDa View All» Epitope: Unknown View All» Immunogen: His-tagged recombinant protein corresponding to human Gemin 2. View All» Clone: 2S7 View All» Isotype: IgG1κ View All» Background Information: Gemin-2 (also known as SIP1 or SMN interacting protein1) is a part of the SMN complex. The SMN complex plays a role in RNA metabolism and in splicing regulation. As part of the SMN complex Gemin-2 interacts directly with Gemin-5 in a heteromeric complex that includes Gemin-3, Gemin-4, Gemin-6. This macromolecular complex (SMN complex) mediates assembly of spliceosomal snRNA complexes containing U1 and U5. Gemin2 plays an important role in snRNP assembly through the stabilization of the SMN oligomer/complex via novel self-interaction. View All» Species Reactivity:

• Human

• Mouse

• Xenopus
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse and xenopus based on 100% sequence homology. View All» Application Notes: Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP. (Battle, D., et al. (2007). J Biol Chem. 282(38):27953-27959.) View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 1 µg/ml of this antibody detected Gemin2 on 10 µg of HeLa cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O14893 View All» Entrez Gene Number: NP_001009182.1 View All» Gene Symbol:
  • SIP1

  • Gemin-2

  • SIP1-delta
    View All» Alternate Names:
    • Component of gems 2

    • SMN interacting protein 1-delta

    • SMN-interacting protein 1

    • survival interacting protein 1

    • survival of motor neuron protein interacting protein 1

    • GEMIN2

    • Gemin2

    • Component of gems
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunoprecipitation
        View All» UniProt Summary: FUNCTION: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.SUBUNIT STRUCTURE: Part of the core SMN complex that contains SMN1, SIP1/GEMIN2, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts directly with GEMIN5. SUBCELLULAR LOCATION: Nucleus › gem. Cytoplasm. Note: Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm.SEQUENCE SIMILARITIES: Belongs to the gemin-2 family.CAUTION: It is uncertain whether Met-1 or Met-12 is the initiator. View All» Product Name: Anti-Gemin2, clone 2S7 Antibody (04-1465) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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