货号：04-147

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ASC Antibody, clone 2EI-7 | 04-147 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes ASC. View All» Molecular Weight: ~22 kDa View All» Epitope: Unknown View All» Immunogen: Full length recombinant human ASC. View All» Clone: 2EI-7 View All» Isotype: IgG1κ View All» Background Information: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, Bcl10, Apaf-1, ARC, caspase-2 and caspase-9. A novel CARD domain containing protein has been identified in human and mouse and designated ASC and TMS1. Irregular expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells. Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Tested on mouse. Predicted to react with human based on 100% sequence homology. View All» Control: Mouse spleen tissue lysate View All» Quality Assurance: Evaluated by Western Blot on mouse spleen tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected ASC in mouse spleen tissue lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9ULZ3 View All» Entrez Gene Number: NM_145182 View All» Gene Symbol:
  • PYCARD

  • ASC

  • CARD5

  • TMS

  • TMS-1

  • TMS1

  • hASC
    View All» Alternate Names:
    • Caspase recruitment domain-containing protein 5

    • PYD and CARD domain containing

    • PYD and CARD domain-containing protein

    • Target of methylation-induced silencing 1

    • apoptosis-associated speck-like protein containing a CARD

    • caspase recruitment domain protein 5

    • target of methylation-induced silencing-1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Flow Cytometry
        View All» Entrez Gene Summary: This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase 9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.SIZE: 195 amino acids; 21627 Da SUBUNIT: Forms complexes with other DAPIN domain-containing proteins. Interacts with CIAS1/PYPAF1 and PYDC1.SUBCELLULAR LOCATION: Cytoplasm. Note=Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures.TISSUE SPECIFICITY: Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T- cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and Molt 4 lymphocytic leukemia cells.DOMAIN:SwissProt: Q9ULZ3 Interacts with CIAS1/PYPAF1 and PYDC1 via the DAPIN domain.PTM: Phosphorylated.SIMILARITY: Contains 1 CARD domain. & Contains 1 DAPIN domain.MISCELLANEOUS: In breast tumorigenesis, methylation-mediated silencing may affect genes and proteins that act as positive mediators of cell death. View All» Product Name: Anti-ASC, clone 2EI-7 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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