货号：04-1479

品牌：Merck Millipore

规格：150Ug

目录价：￥5062.00

市场价格：￥4302.70

会员价格：￥4049.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-methyl-PP2A Antibody, C subunit, clone 2A10 | 04-1479 View All» Replaces: 04-1479 is a recommended replacement for 05-546. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Recognizes the methylated form of PP2A, catalytic subunit. View All» Molecular Weight: ~36 kDa View All» Immunogen: KLH-conjugated, synthetic peptide (C-βA-RRTPDYFL-Ome) corresponding to amino acids 302-309 of human PP2A catalytic subunit. Clone 2A10. View All» Modifications: Methylation View All» Clone: 2A10 View All» Isotype: IgG1κ View All» Background Information: Type 2 protein serine/threonine phosphatase (PP2A) is a trimer composed of a catalytic C subunit and two regulatory (A and B) subunits; many isoforms for the A and B subunits have been found. PP2A has a high specific activity against the α subunit of phosphorylase kinase and is insensitive to Inhibitor-2. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and by its high sensitivity to inhibition by okadaic acid. It is also thought to be the principal down-modulator of serine/threonine kinase cascades. PP2B requires Ca2+/calmodulin for activity, and is an activator of NFAT transcription factors. PP2C requires Mg2+, but is insensitive to okadaic acid, microcystin LR, or the calmodulin inhibitor trifluoperazine. View All» Species Reactivity:

• Human

• Mouse

• Yeast (S. cerevisiae)

• Rat

• Pig

• Rabbit

• Chicken

• Drosophila
  View All» Species Reactivity Note: Human, mouse and yeast. Predicted to cross react with rat, pig, rabbit, chicken and Drosophila. View All» Control: Lysates from a yeast wild type strain (strain lacking the methyltransferase, delta PPM1) and a strain lacking the methylestrase, delta PPE1. View All» Quality Assurance: Evaluated by western blot on lysates from a yeast wild type strain (strain lacking the methyltransferase, delta PPM1) and a strain lacking the methylestrase, delta PPE1.Western Blot Analysis: 1-5 µg/mL of this antibody detected the methylated form of PP2A catalytic subunit in yeast lysates lacking the methylestrase (increased methylation). Treatment of the blot with 0.2 M NaOH will demethylate proteins, thus eliminating detection of PP2A. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl and 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap. View All» UniProt Number: P67775 View All» Entrez Gene Number: NP_002706.1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-methyl-PP2A, C subunit, clone 2A10 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 150 µg View All» Format: Purified View All» Host: Mouse View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：https://www.16ao.com/thread-131469.htm
  © Merck Millipore代理04-1479 Anti-methyl-PP2A Antibody, C subunit, clone 2A10;store at +2℃ to +8℃，产品报价联系微信jinshanbio