货号：04-1503

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interleukin 18 (IL-18) Antibody, clone CPTC-IL18-1 | 04-1503 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes IL-18. View All» Molecular Weight: ~23 kDa View All» Epitope: Unknown View All» Immunogen: Recombinant protein corresponding to full length human IL-18. View All» Clone: CPTC-IL18-1 View All» Isotype: IgG1κ View All» Background Information: IL-18 is a proinflammatory cytokine, a member of the IL-1 superfamily, involved in cell-mediated immunity in the presence of microbial infection. Stimulation by IL-18 is causal to the release of interferon-γ by NK cells and some T cells, which in turn serves to activate macrophages. Inflammatory cytokines, such as IL-18, can incite the degeneration of nerve cells and increase the production of plaque typical to Alzheimer’s disease. IL-18 has been of interest in studying several disease pathways including endometriosis, lupus nephritis and Alzheimer’s disease. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: Human Serum View All» Quality Assurance: Evaluated by Western Blot in human serum.Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-18 in 10 µg of human serum. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q14116 View All» Entrez Gene Number: NP_001553 View All» Gene Symbol:

• IGIF1

• IL18

• IL-18

• IL1F4

• IL-1g
  View All» Alternate Names:
  • interleukin 18 (interferon-gamma-inducing factor)

  • IL-1 gamma

  • interleukin-18

  • interleukin 18

  • Iboctadekin

  • Interferon-gamma-inducing factor

  • IFN-gamma-inducing factor

  • Interleukin-1 gamma
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.SUBCELLULAR LOCATION: Secreted. SEQUENCE SIMLARITIES: Belongs to the IL-1 family. View All» Product Name: Anti-Interleukin 18 (IL-18), clone CPTC-IL18-1 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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