货号：04-151

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IFNAR-1 Antibody, clone MARI-5A3 | 04-151 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the extracellular domain of IFNAR-1. View All» Molecular Weight: 63 kDa calculated View All» Epitope: Extracellular Domain View All» Immunogen: Recombinant protein corresponding to the extracellular domain of mouse IFNAR-1. View All» Clone: MARI-5A3 View All» Isotype: IgG1κ View All» Background Information: Interferon alpha/beta receptor 1 (IFNAR-1) is a single-pass type I membrane protein containing three fibronectin type-III domains and is a member of the type II cytokine receptor family. IFNAR-1 serves as an interferon receptor specific to interferons alpha and beta, a family of type I interferons critical to the promotion and the linking of adaptive and innate immune response. Type I interferons all bind to a heterodimeric receptor composed of two subunits, IFNAR-1 and IFNAR-2. The binding of the type I IFNs initializes tyrosine phosphorylation for several proteins such as; IFNR alpha/beta subunits, JAKs, STAT, and TYK2 proteins. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)Neutralizing Assay: A previous lot was used by an independent laboratory in neutralization studies. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.) View All» Control: BALB/c splenocytes View All» Quality Assurance: Evaluated by Flow Cytometry in BALB/c splenocytes.Flow Cytometry Analysis: 5 µg of this antibody detected IFNAR-1 in BALB/c splenocytes. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P33896 View All» Entrez Gene Number: NP_034638 View All» Gene Symbol:

• IFRC

• IFNAR1

• IFNBR

• IFN-R-1

• IFNAR

• AVP

• CRF2-1
  View All» Alternate Names:
  • interferon (alpha, beta and omega) receptor 1

  • beta-type antiviral protein

  • alpha-type antiviral protein

  • Type I interferon receptor 1

  • Cytokine receptor family 2 member 1

  • interferon-beta receptor 1

  • Cytokine receptor class-II member 1

  • IFN-alpha-REC

  • interferon-alpha/beta receptor alpha chain

  • IFN-alpha/beta receptor 1

  • interferon alpha/beta receptor 1

  • human interferon-alpha receptor (HuIFN-alpha-Rec)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunoprecipitation

    • Western Blotting

    • Neutralizing
      View All» UniProt Summary: FUNCTION: Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SEQUENCE SIMILARITIES: Belongs to the type II cytokine receptor family.Contains 3 fibronectin type-III domains. View All» Product Name: Anti-IFNAR-1, clone MARI-5A3 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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