货号：04-1526

品牌：Merck Millipore

规格：

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Vitamin D receptor Antibody, clone 9A7 | 04-1526 View All» Replaces: 04-1526 is a recommended replacement for MAB1360. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody detects vitamin D receptor. View All» Molecular Weight: ~53 kDa View All» Epitope: a.a. 89-105 View All» Immunogen: Partially purified chicken intestinal vitamin D receptor. View All» Clone: 9A7 View All» Isotype: IgG2bκ View All» Background Information: Vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or transrepression of specific gene products. In humans, the vitamin D receptor is encoded by the VDR gene. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows similarity of sequence to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. View All» Species Reactivity:

• Human

• Vertebrates
  View All» Species Reactivity Note: Human. Broad species reactivity expected. View All» Application Notes: Immunohistochemistry (paraffin): Optimal Staining with Citrate, pH 6.0. Epitope Retrieval: Hypothalamus Neurons.Immunoprecipitation: A previous lot of this antibody was used in IP.Blocking: A previous lot was used in blocking/inhibition assays.Purification: A previous lot was used for purification purposes. View All» Control: MCF7 cell lysate View All» Quality Assurance: Evaluated by western blot on MCF7 cell lysate.Western Blot Analysis: 0.5-2 µg/mL of this antibody detected vitamin D receptor in MCF7 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4) 150 mM NaCl and 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: P11473 View All» Entrez Gene Number: NM_000376.2 View All» Gene Symbol: NR1I1 View All» Alternate Names:
  • 1,25-dihydroxyvitamin D3 receptor

  • Nuclear receptor subfamily 1 group I member 1

  • vitamin D (1,25- dihydroxyvitamin D3) receptor

  • vitamin D (1,25-dihydroxyvitamin D3) receptor
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)

    • Immunoprecipitation

    • Affects Function
      View All» UniProt Summary: FUNCTION: Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Plays a central role in calcium homeostasis. SUBUNIT STRUCTURE: Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. SUBCELLULAR LOCATION: Nucleus. DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.POLYMORPHISM: Genetic variations in VDR may determine Mycobacterium tuberculosis susceptibility [MIM:607948].INVOLVEMENT IN DISEASE: Defects in VDR are the cause of type IIA rickets [MIM:277440]; also known as hypocalcemic vitamin D-resistant rickets (HVDRR). HVDRR is most frequently an autosomal recessive disorder characterized by severe rickets, hypocalcemia and secondary hyperparathyroidism.SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain.CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.SEQUENCE CAUTION: The sequence AAP88938.1 differs from that shown. Reason: Erroneous gene model prediction. View All» Product Name: Anti-Vitamin D receptor, clone 9A7 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rat View All»
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