货号：MAB4126

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LRP Antibody, clone LRP-56 | MAB4126 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: LRP-56 reacts with an internal epitope of the LRP/Major Vault Protein (P110), which is strongly overexposed in various human non-P-glycoprotein MDR tumor cell lines. CLONE NAME: LRP-56. Hybridoma cell line obtained by fusion of lymph node cells from immunized mouse (inbred Balb/C strain) with SP2/O mouse myeloma cells. View All» Clone: LRP-56 View All» Isotype: IgG2b View All» Species Reactivity: Human View All» Application Notes: Flow Cytometry Immunohistochemistry on frozen and paraffin embedded tissue sections: 1:20. Immunocytochemistry on air-dried or acetone-fixed cells. Note: for cellular detection permeabilization is required. Optimal working dilutions must be determined by end user. View All» Presentation: Liquid containing 0.1% sodium azide and 1.0% BSA. View All» Storage Conditions: Store at -20°C in undiluted aliquots. May be stored at 2-8°C for short term use. Avoid repeated freeze-thaw cycles. View All» UniProt Number: Q07954 View All» Entrez Gene Number: NM_002332.2 View All» Gene Symbol:

• LRP1

• LRP

• TGFBR5

• APOER

• A2MR

• FLJ16451

• APR

• CD91

• MGC88725
  View All» Alternate Names: Lung Resistance-related Protein; MVP; Major Vault Protein View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Immunohistochemistry (Paraffin)
    View All» UniProt Summary: FUNCTION: SwissProt: Q07954 # Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.SIZE: 4544 amino acids; 504575 Da SUBUNIT: Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa amino-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1.SUBCELLULAR LOCATION: Low-density lipoprotein receptor-related protein 1 85 kDa SUBUNIT: Cell membrane; Single-pass type I membrane protein. & Low-density lipoprotein receptor-related protein 1 515 kDa SUBUNIT: Cell membrane; Peripheral membrane protein; Extracellular side. & Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.TISSUE SPECIFICITY: Most abundant in liver, brain and lung.PTM: Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non- covalently associated. Gamma-secretase-dependent cleavage of LRP- 85 releases the intracellular domain from the membrane. & The N-terminus is blocked. & Phosphorylated on serine and threonine residues. & Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.SIMILARITY: SwissProt: Q07954 ## Belongs to the LDLR family. & Contains 22 EGF-like domains. & Contains 31 LDL-receptor class A domains. & Contains 34 LDL-receptor class B repeats. View All» Brand Family: Chemicon View All» Product Name: Anti-LRP Antibody, clone LRP-56 | MAB4126 View All» Concentration: Approximately 0.1mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Culture Supernatant View All» Host: Mouse View All»
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