货号：04-1564

品牌：Merck Millipore

规格：100UL

目录价：￥5249.00

市场价格：￥4461.65

会员价格：￥4199.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Estrogen Receptor α Antibody, clone F3-A | 04-1564 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Estrogen Receptor α. View All» Molecular Weight: ~ 67 kDa View All» Epitope: Unknown View All» Immunogen: Linear peptide corresponding to human Estrogen Receptor α. View All» Isotype: IgG1κ View All» Background Information: Estrogen Receptor α (ERα) is a 65 kDa nuclear hormone receptor. This steroid hormone receptor is involved in the regulation of eukaryotic gene expression and affects cellular proliferation and differentiation in target tissues. ERα is a ligand-activated transcription factor and upon being bound by a ligand such as estrogen, a conformational change occurs that allows dimerization and binding to an estrogen response element. When bound to DNA, Estrogen Receptor α can positively or negatively regulate gene transcription. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Two ERs are known, ERα, classically known as ER, and ERβ. The Estrogen Receptor is believed to play an important role in the growth and development of a subset of hormone dependent human breast cancers. ERβ is expressed in prostate, ovary, and other reproductive organs. Although its steroid specificity is very similar to that of the ERα, the molecular mechanisms regulating the transcriptional activity of ERβ may be distinct from those regulating ERα. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected Estrogen Receptor α in A431 cells. View All» Control: Mouse ovary tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse ovary tissue lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected Estrogen Receptor α on 10 µg of mouse ovary tissue lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified mouse monoclonal IgG1κ preservative-free ascites. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P03372 View All» Entrez Gene Number: NP_000116 View All» Gene Symbol:
  • ESR1

  • ER

  • ER-alpha

  • ESR

  • ESRA

  • Era

  • NR3A1
    View All» Alternate Names:
    • Estradiol receptor

    • Nuclear receptor subfamily 3 group A member 1

    • estrogen receptor 1

    • estrogen receptor alpha

    • estrogen receptor alpha delta 4*,5,6,7*/633 isoform

    • estrogen receptor alpha delta 6,7 isoform
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.SIZE: 595 amino acids; 66216 Da SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with JARID1A. Interacts with SMARD1. Interacts with SLC30A9 (By similarity). Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1.SUBCELLULAR LOCATION: Nucleus.DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.PTM: Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. Contains 1 nuclear receptor DNA-binding domain.MISCELLANEOUS: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone- receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites. ... View All» Product Name: Anti-Estrogen Receptor α, clone F3-A Antibody View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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