货号：MAB4145

品牌：Merck Millipore

规格：1EA

目录价：￥4492.88

市场价格：￥3818.95

会员价格：￥3594.30

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-BCRP Antibody, clone BXP-34 | MAB4145 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: This antibody reacts with an internal epitope of the Breast Cancer Resistance Protein (BCRP), a 70 kDa transmembrane half-transporter which is involved in multidrug resistance. The antibody does not cross-react with human MDR1, MRP1, MRP2 or MRP5 gene products. View All» Molecular Weight: 70 kDa View All» Immunogen: The Mitoxanthrone resistant, BCRP-overexpressing cell line MCF7-MR. View All» Clone: BXP-34 View All» Isotype: IgG1 View All» Background Information: The 72 kDa breast cancer resistance protein (BCRP) is the second member of the subfamily G of the human ATP binding cassette (ABC) transporter superfamily and thus also designated as ABCG2. BCRP is a half-transporter consisting of only 1 nucleotide binding domain followed by 1 membrane-spanning domain. Current experimental evidence suggests that BCRP may function as a homodimer or homotetramer. Overexpression of BCRP is associated with high levels of resistance to a variety of anticancer agents. BCRP expression has been detected in a large number of hematological malignancies and solid tumors, indicating that this transporter may play an important role in clinical drug resistance of cancers. In addition to its role to confer resistance against chemotherapeutic agents, BCRP actively transports structurally diverse organic molecules, conjugated or unconjugated, such as estrone-3-sulfate, 17-β-estradiol 17-(β-D-glucuronide), and methotrexate. BCRP is highly expressed in the placental syncytiotrophoblasts, in the apical membrane of the epithelium in the small intestine, in the liver canalicular membrane, and at the luminal surface of the endothelial cells of human brain microvessels. This strategic and substantial tissue localization indicates that BCRP also plays an important role in absorption, distribution, and elimination of drugs that are BCRP substrates. View All» Species Reactivity: Human View All» Application Notes: Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections Not suitable for paraffin-embedded tissues or for Western blotting Optimal working dilutions must be determined by end user. View All» Applications Not Recommended:

• Western Blotting

• Immunohistochemistry (Paraffin)
  View All» Control: MCF-7 cells View All» Presentation: Liquid containing 0.7% BSA and 0.1% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for up to 6 months. For long-term storage store at -20°C. View All» UniProt Number: Q9UNQ0 View All» Entrez Gene Number: NM_004827.2 View All» Gene Symbol:
  • ABCG2

  • BCRP

  • BMDP

  • BCRP1

  • MXR

  • ABC15

  • ABCP

  • EST157481

  • MGC102821

  • MXR1

  • MRX

  • CDw338
    View All» Alternate Names: Breast Cancer Resistance Protein; Placenta-specific ATP Binding Cassette Transporter; ATP-binding Cassette, Sub Family G, Member 2 (ABCG2) View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry
      View All» Entrez Gene Summary: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. View All» UniProt Summary: FUNCTION: SwissProt: Q9UNQ0 # Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123.SIZE: 655 amino acids; 72314 Da SUBUNIT: Monomer or homodimer; disulfide-linked.SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Highly expressed in placenta. Low expression in small intestine, liver and colon.PTM: Glycosylation-deficient ABCG2 is normally expressed and functional.SIMILARITY: SwissProt: Q9UNQ0 ## Belongs to the ABC transporter family. ABCG (White) subfamily. & Contains 1 ABC transporter domain. View All» Brand Family: Chemicon View All» Product Name: Anti-BCRP Antibody, clone BXP-34 | MAB4145 View All» Concentration: 0.25mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Culture Supernatant View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-131538.htm
      © Merck Millipore代理MAB4145 Anti-BCRP Antibody, clone BXP-34，产品报价联系微信jinshanbio