货号：MAB4148

品牌：Merck Millipore

规格：100Ug

目录价：￥4752.00

市场价格：￥4039.20

会员价格：￥3801.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MRP2 Antibody, clone M2 I-4 | MAB4148 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: This antibody reacts with an internal epitope of MRP2, a 190-200 kDa transmembrane protein previously known as the canalicular multi-organic anion transporter (cMOAT). MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines. This antibody does not cross-react with the human MDR1, MRP1, MRP3 or MRP5 gene products. View All» Immunogen: Fusion protein of MRP2 containing aa 215-310 of the protein. View All» Clone: M2 I-4 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Western blotting: 1:20 - 1:50 with anti-mouse HRP Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections Optimal working dilutions must be determined by end user. View All» Presentation: Liquid containing 0.7% BSA and 0.1% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for up to 6 months. For long-term storage store at -20°C. View All» UniProt Number: Q92887 View All» Entrez Gene Number: NM_000392.2 View All» Gene Symbol:

• ABCC2

• MRP2

• ABC#

• CMOAT1

• CMOAT

• ABC30

• CMRP

• DJS

• KIAA1010

• cMRP
  View All» Alternate Names: cMOAT View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunocytochemistry

  • Immunohistochemistry
    View All» Entrez Gene Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. View All» UniProt Summary: FUNCTION: SwissProt: Q92887 # Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.SIZE: 1545 amino acids; 174191 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.DISEASE: SwissProt: Q92887 # Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.SIMILARITY: SwissProt: Q92887 ## Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MRP2 Antibody, clone M2 I-4 | MAB4148 View All» Concentration: 0.25 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Culture Supernatant View All» Host: Mouse View All»
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