货号：04-1584

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interleukin-2 (IL-2) Antibody, clone 3F9 | 04-1584 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~15 kDa observed View All» Immunogen: Full length recombinant protein corresponding to human IL-2. View All» Clone: AB12.38.35C3.3F9 View All» Isotype: IgG2bκ View All» Background Information: Interleukin-2 (IL-2) is commonly considered a pro-inflammatory cytokine that stimulated T-cell-dependent immune reactions and control regulatory T cells or Tregs. Structurally, IL-2 is thought to have a 4-helix-bundle-type fold and uses a novel type I cytokine receptor (IL-21R) with the common gamma chain cytokine receptor. IL-2 also may intensify Th1-mediated diseases, including autoimmune arthritis and may also be interesting clinical targets for those diseases. IL-2 has also been implicated as a possible therapy for infection and cancer. Anti-tumor therapies that include a combination of recombinant IL-2 and recombinant interferon alpha have been promising in clinical studies. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: Human IL-2 recombinant protein View All» Quality Assurance: Evaluated by Western Blot in lysate from cells expressing human IL-2 recombinant protein.Western Blot Analysis: 0.5 µg/mL of this antibody detected 10 µg of human IL-2 recombinant protein. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P60568 View All» Entrez Gene Number: NP_000577 View All» Gene Symbol:

• IL2

• IL-2

• TCGF
  View All» Alternate Names:
  • interleukin 2

  • involved in regulation of T-cell clonal expansion

  • aldesleukin

  • T cell growth factor

  • lymphokine

  • Aldesleukin

  • interleukin-2

  • T-cell growth factor
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.SUBCELLULAR LOCATION: Secreted. INVOLVEMENT IN DISEASE: Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.PHARMACEUTICAL USE: Available under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.SEQUENCE SIMILARITIES: Belongs to the IL-2 family.SEQUENCE CAUTION: The sequence AAA59140.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Interleukin-2 (IL-2), clone 3F9 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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