货号：04-1593

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Activation-induced cytidine deaminase (AID) Antibody, clone EK2-5G9 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes activation-induced cytidine deaminase (AID). View All» Molecular Weight: ~24 kDa.A non-specific band may be observed at ~18 kDa in western blot. View All» Epitope: Unknown View All» Immunogen: KLH-conjugated linear peptide corresponding to human AID. View All» Clone: EK2-5G9 View All» Isotype: IgG2bκ View All» Background Information: Activation-induced cytidine deaminase (AID) is a 24 kDa, RNA-editing protein that is necessary for the initiation of both somatic hypermutation (SHM) and class switch recombination (CSR) of the Ig gene through the production of U:G mismatches in DNA, and is primarily found in activated B cells. AID expression has also been observed in several varying types of B cell lymphomas such as; Burkitt’s lymphoma, Hodgkin’s lymphoma, hairy cell lymphoma, follicular lymphoma, mantle cell lymphoma, mucosa-associated lymphoid tissue lymphoma, and mediastinal B cell lymphoma. Mutations in AID expression are causal to autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2), which is characterized by serum containing IgM but lacking IgG, IgA and IgE, which leads to severe susceptibility to bacterial infections. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunohistochemistry Analysis: A previous lot detected AID in germinal centre B-cells of dark centroblast-rich tissue, as well as lymphocytic and histiocytic cells (Greiner, A., et al. (2005). View All» Control: Raji cell lysate View All» Quality Assurance: Evaluated by Western Blot in Raji cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected AID in 10 µg of Raji cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9GZX7 View All» Entrez Gene Number: NP_065712.1 View All» Gene Symbol:

• AID

• ARP2

• HIGM2

• CDA2
  View All» Alternate Names:
  • activation-induced cytidine deaminase

  • integrated into Burkitt's lymphoma cell line Ramos

  • Cytidine aminohydrolase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq]. View All» UniProt Summary: FUNCTION: RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.CATALYTIC ACTIVITY: Cytidine + H2O = uridine + NH3.COFACTOR: Zinc (By similarity).TISSUE SPECIFICITY: Strongly expressed in lymph nodes and tonsils.INVOLVEMENT IN DISEASE: Defects in AICDA are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]. HIGM2 is characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.SEQUENCE SIMILARITIES: Belongs to the cytidine and deoxycytidylate deaminase family. View All» Product Name: Anti-Activation-induced cytidine deaminase (AID), clone EK2-5G9 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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