货号：04-210

品牌：Merck Millipore

规格：

目录价：￥3767.00

市场价格：￥3201.95

会员价格：￥3013.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-c-Jun (C-term) Antibody, clone EP693Y, Rabbit | 04-210 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: This antibody recognizes c-Jun at its C-Terminus. View All» Molecular Weight: 39 kDa View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide directed against the C-terminus of human c-Jun. View All» Clone: EP693Y View All» Isotype: IgG View All» Background Information: Jun is a component of the transcription factor AP-1, and can constitute AP-1 activity either as a homodimer or as a heterodimer with Fos. By contrast with Fos, Jun is expressed constitutively, and can be activated by phosphorylation of serines 63 and/or 73. These sites are targets for the SAPK1/JNK family of protein kinases, and their phosphorylation states can be monitored using antibodies specific for the phospho-epitopes. In addition, Jun is phosphorylated by GSK3 on sites which inhibit Jun activity. Since GSK3 is inactivated by Akt, the Akt pathway results in Jun activation. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. Not expected to react with mouse and rat. View All» Non-Reactive Species:

• Mouse

• Rat
  View All» Application Notes: IImmunoprecipitation: 1:50 dilution was used in immunoprecipitation of c-Jun.Immunohistochemistry Analysis:A 1:100-250 dilution of anti-c-Jun, (C-term) EP693Y was used in IHC Immunohistochemical analysis of paraffin-embedded human colon carcinoma.Immunocytochemistry Analysis: View All» Control: HEK293 whole cell lysate. View All» Quality Assurance: Routinely evaluated by Western Blot on HEK293 whole cell lysate.Western Blot Analysis:A 1:5000 dilution of this lot was used to detect c-Jun HEK293 whole cell lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified rabbit monoclonal IgG in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P05412 View All» Entrez Gene Number: NM_002228 View All» Gene Symbol:
  • AP-1

  • AP1

  • OTTHUMP00000010036

  • c-Jun

  • p39
    View All» Alternate Names:
    • Activator protein 1

    • Jun activation domain binding protein

    • Proto-oncogene c-jun

    • V-jun avian sarcoma virus 17 oncogene homolog

    • enhancer-binding protein AP1

    • jun oncogene

    • v-jun sarcoma virus 17 oncogene homolog

    • v-jun sarcoma virus 17 oncogene homolog (avian)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: SwissProt: P05412 # Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.SIZE: 331 amino acids; 35676 Da SUBUNIT: Interacts with FOS to form a dimer. Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.SUBCELLULAR LOCATION: Nucleus.PTM: Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.SIMILARITY: SwissProt: P05412 ## Belongs to the bZIP family. Jun subfamily. & Contains 1 bZIP domain. View All» Brand Family: Upstate View All» Product Name: Anti-c-Jun (C-term), clone EP693Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Culture Supernatant View All» Host: Rabbit View All»
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