货号：04-217

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-c-Myc (Thr58/Ser62) Antibody | 04-217 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: c-Myc when phosphorylated on residues Thr58/Ser62. View All» Molecular Weight: 57 kDa View All» Epitope: phosphorylated Thr58/Ser62 View All» Immunogen: Synthetic peptide corresponding to sequence surrounding and including phosphorylated Thr58 and Ser62 of human c-Myc. View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Background Information: Myc is a member of the helix-loop-helix-leucine zipper (bHLH-LZ) family of transcription factors, which dimerizes with Max to activate transcription of some genes and repress others. As Max is essential for Myc activity, the availability of Max is a regulatory mechanism for Myc activity, and members of the Mad family of proteins compete with Myc for Max. View All» Species Reactivity:

• Human

• Mouse
  View All» Non-Reactive Species: Rat View All» Application Notes: Suggested dilutions: Western Blot: 1:10,000 Immunocytochemistry: 1:50-1:100 Immunoprecipitation: 1:100 View All» Control: Calyculin/Okadaic acid-treted A431 lysate View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Unpurified View All» Presentation: 100 μL of rabbit monoclonal IgG in 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P01106 View All» Entrez Gene Number: NP_002458.2 View All» Gene Symbol:
  • c-Myc

  • C-Myc

  • MYC

  • C-MYC
    View All» Alternate Names:
    • Transcription factor p64

    • avian myelocytomatosis viral oncogene homolog

    • myc proto-oncogene protein

    • v-myc avian myelocytomatosis viral oncogene homolog

    • v-myc myelocytomatosis viral oncogene homolog (avian)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunofluorescence

      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. View All» UniProt Summary: FUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.SIZE: 439 amino acids; 48804 Da SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B.SUBCELLULAR LOCATION: Nucleus.PTM: Phosphorylated by PRKDC.DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-c-Myc (Thr58/Ser62), clone E203 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Culture Supernatant View All» Host: Rabbit View All»
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