货号：MAB4311

品牌：Merck Millipore

规格：100Y56

目录价：￥4563.00

市场价格：￥3878.55

会员价格：￥3650.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nucleostemin Antibody | MAB4311 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Immunogen: Recombinant GST-Human fusion protein View All» Clone: 9D5.3 View All» Isotype: IgG2bκ View All» Background Information: Nucleostemin has been identified as a nucleolar protein that plays a role in the self-renewal mechanism of a variety of stem cells. Analysis of gene expression showed that both undifferentiated ES cells, Neural & Hematopoietic stem cells and a number of cancer cells express Nucleostemin. Expression was not detected following stem cell differentiation into mature cell types. The identification of factors that influence self renewal are important for the development of therapeutic applications of stem cells and also for the development of cancer treatments. Monoclonal antibodies to Human nucleostemin will facilitate the analysis of self-renewal in both stem cells and cancer cells. View All» Species Reactivity:

• Human

• Mouse
  View All» Presentation: Static cell culture supernatant fluid View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: Q9BVP2 View All» Entrez Gene Number:
  • NM_014366.4

  • NM_206825.1

  • NM_206826.1
    View All» Gene Symbol:
    • GNL3

    • C77032

    • Nucleostemin

    • NS

    • MGC800

    • NNP47

    • E2IG3

    • nucleostemin
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: SwissProt: Q9BVP2 # May be required to maintain the proliferative capacity of stem cells.SIZE: 549 amino acids; 61997 Da SUBUNIT: May interact with p53/TP53 via its basic domain (By similarity).SUBCELLULAR LOCATION: Nucleus (By similarity). Nucleus, nucleolus (By similarity). Note=Shuttles between the nucleus and nucleolus (By similarity).DOMAIN: SwissProt: Q9BVP2 The basic domain (B) allows nucleolar localization in the absence of GTP. The intermediate domain (I) inhibits nucleolar localization by the B domain and is required for exit from the nucleolus. Exit from the nucleolus to the nucleoplasm requires both the I and the acidic (A) domains, and may be triggered by GTP hydrolysis (By similarity).SIMILARITY: Belongs to the MMR1/HSR1 GTP-binding protein family. View All» Brand Family: Chemicon View All» Product Name: Anti-Nucleostemin Antibody | MAB4311 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Culture Supernatant View All» Host: Mouse View All»
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