货号：MAB4313P

品牌：Merck Millipore

规格：

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD93 Antibody, clone R3, Phycoerythrin conjugated | MAB4313P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human CD93 (C1qRp). View All» Immunogen: C1q tail binding proteins View All» Clone: R3 View All» Isotype: IgM View All» Background Information: CD93 (C1qRp) is a 90-120 kDa protein that is highly expressed on monocytes/macrophages, neutrophils and granulocytes. CD93 is not expressed upon T and B lymphocytes. C1qRp binds C1q, the recognition subunit of the first component (C1) of the complement pathway, as well as MBL (Mannose-binding-lectin) and SPA (Pulmonary Surfactant Protein A). However, CD93 is not necessary for the binding of C1q or for inducing C1q-mediated enhancement of phagocytic activity. Recent evidence suggests that CD93 may define a new human stem cell population with hematopoietic and hepatic potential 3. View All» Species Reactivity: Human View All» Application Notes: Immunocytochemistry: 5-10 μg/ml. Fixative: 4% Paraformaldehyde / PBS. Blocking buffer: 2% BSA / 2% Normal serum / PBS. Dilution Buffer: 2% BSA / 2% Normal serum / PBS. Incubation Times/Temperature: 1 hour at room temperature FACS Analysis: Suggested dilution/number of cells: 2 μg/million cells. Fixation/Permeabilization used: 1% Paraformaldehyde Optimal working dilutions must be determined by end user. View All» Control: Positive Control: U937 monocytesNegative Control: T cells View All» Presentation: R-Phycoerythrin-conjugated immunoglobulin. Liquid in PBS, pH 7.4, with 0.1% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months from date of receipt. Protect from light. View All» UniProt Number: Q9NPY3 View All» Entrez Gene Number: NM_012072.3 View All» Gene Symbol:

• CD93

• MXRA4

• C1qRp

• C1qR(P)

• C1qR

• dJ737E23.1

• C1QR1

• CDw93

• p

• C1qRP
  View All» Alternate Names: Complement C1q Receptor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. View All» Key Applications: Flow Cytometry View All» UniProt Summary: FUNCTION: SwissProt: Q9NPY3 # Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.SIZE: 652 amino acids; 68560 Da SUBUNIT: Interacts with HCV core protein.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.PTM: N- and O-glycosylated.SIMILARITY: SwissProt: Q9NPY3 ## Contains 1 C-type lectin domain. & Contains 5 EGF-like domains. View All» Brand Family: Chemicon View All» Product Name: Anti-CD93 Antibody, clone R3, Phycoerythrin conjugated | MAB4313P View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Phycoerythrin View All» Host: Mouse View All»
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