货号：MAB4336

品牌：Merck Millipore

规格：

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MDR1 Antibody, clone 5A12.2 | MAB4336 View All» Replaces: MAB433 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: 5A12.2 recognizes human P-glycoprotein encoded by the MDR1 (ABCB1) gene, a member of the ABC superfamily of ATP-binding cassette transporters. Expression of P-glycoprotein is associated with ATP-dependent transmembrane efflux of chemically diverse compounds from the cell and is the major component of multidrug resistance in human tumors. View All» Immunogen: Human MDR-transfected NIH3T3 cells View All» Clone: 5A12.2 View All» Isotype: IgG2b View All» Species Reactivity: Human View All» Application Notes: Immunohistochemistry on frozen and paraffin embedded tissue sections: 1:40. Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in 0.02M PBS pH 7.6, 0.25M NaCl with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: P08183 View All» Entrez Gene Number: NM_000927.3 View All» Gene Symbol:

• ABCB1

• PGY1

• MGC163296

• CD243

• GP170

• P-gp

• MDR1

• CLCS

• ABC20

• EC 3.6.3.44
  View All» Alternate Names: P-glycoprotein; CD243; p170; Pgp View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunohistochemistry

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. View All» UniProt Summary: FUNCTION: SwissProt: P08183 # Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.SIZE: 1280 amino acids; 141463 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed in liver, kidney, small intestine and brain.SIMILARITY: SwissProt: P08183 ## Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains. View All» Brand Family: Chemicon View All» Product Name: Anti-MDR1 Antibody, clone 5A12.2 | MAB4336 View All» Concentration: Varies by lot. See lot specific Certificate of Analysis/Datasheet for concentration information. View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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