货号：MAB4339

品牌：Merck Millipore

规格：

目录价：￥3999.00

市场价格：￥3399.15

会员价格：￥3199.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-REN-1 Antibody, clone 2G6.2 | MAB4339 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Immunogen: Recombinant GST-Murine fusion protein, murine REN-1 View All» Clone: 2G6.2 View All» Isotype: IgG2bκ View All» Background Information: REN is a developmentally regulated gene that promotes neural cell differentiation. REN expression is upregulated by embryonic stem cells, following induction by neurogenic signals. It may play a role in neural promotion and can serve as both a marker and regulator of neuronal differentiation. View All» Species Reactivity:

• Mouse

• Rat
  View All» Presentation: Liquid in PBS with 0.1% sodium azide View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: P00797 View All» Entrez Gene Number: NM_000537.2 View All» Gene Symbol:
  • REN

  • Angiotensinogenase

  • angiotensinogenase

  • renin

  • FLJ10761

  • EC 3.4.23.15
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. View All» UniProt Summary: FUNCTION: SwissProt: P00797 # Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.SIZE: 406 amino acids; 45057 Da SUBUNIT: Interacts with ATP6AP2.SUBCELLULAR LOCATION: Secreted. Membrane. Note=Associated to membranes via binding to ATP6AP2.DISEASE: SwissProt: P00797 # Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).SIMILARITY: SwissProt: P00797 ## Belongs to the peptidase A1 family. View All» Brand Family: Chemicon View All» Product Name: Anti-REN-1 Antibody, clone 2G6.2 | MAB4339 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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