货号：04-251

品牌：Merck Millipore

规格：

目录价：￥4891.00

市场价格：￥4157.35

会员价格：￥3912.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-20S proteasome subunit β5i, clone LMP7-1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes proteasome subunit beta type 8 View All» Molecular Weight: 30 kDa View All» Immunogen: Recombinant human proteasome subunit β5i View All» Clone: LMP7-1 View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Rat
  View All» Presentation: 100 µL of concentration 2.1mg/ml purified immunoglobulin from cell culture supernatant in 100 mM NaCl, 25 mM Tris (HCl), pH 8.0, containing 0.01 M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4. View All» Storage Conditions: Stable for 1 year at -20°C from date of shipment for up to 12 months. View All» UniProt Number: P28062 View All» Entrez Gene Number:
  • NM_004159.4

  • NM_148919.3
    View All» Gene Symbol:
    • PSMB8

    • OTTHUMP00000062981

    • D6S216

    • LMP7

    • RING10

    • D6S216E

    • Y2

    • MGC1491
      View All» Alternate Names: Lmp7; proteasome subunit beta type 8 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. View All» UniProt Summary: FUNCTION: SwissProt: P28062 # The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.SIZE: 276 amino acids; 30354 Da SUBUNIT: The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure. This subunit is part of the immunoproteasome where it displaces the equivalent housekeeping subunit PSMB5. Directly interacts with POMP.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).SIMILARITY: SwissProt: P28062 ## Belongs to the peptidase T1B family. View All» Brand Family: Upstate View All» Product Name: Anti-20S proteasome subunit β5i, clone LMP7-1 View All» Concentration: 2.1mg/ml View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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