货号：MAB4344

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GATA-4 Antibody, clone 13G4.2 | MAB4344 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~50 kDa observed An additional band was observed 15~20 kDa, which could be a cleavage of GATA-4. View All» Immunogen: GST-tagged recombinant protein corresponding to human GATA-4. View All» Clone: 13G4.2 View All» Isotype: IgG2aκ View All» Background Information: GATA4 (GATA binding factor-4) is a member of the GATA family of transcription factors and is located primarily in the nucleus. GATA4 is a transcriptional activator of ANF and also acts in conjuction with NKX2-5, ZNF260, NFATC4 and LMCD1. GATA4's activation of ANF can be repressed through JARID2 interaction. GATA4 is involved in embryogenesis and in myocardial differentiation and function and is associated with heart septal defects. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Application Notes: Immunohistochemistry Analysis: A 1:500 dilution from a previous lot detected GATA-4 in anal carcinoma/diffusive squamous cell carcinoma and prostate carcinoma tissues. View All» Control: Mouse heart tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse heart tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected GATA-4 in 10 µg of mouse heart tissue lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P43694 View All» Entrez Gene Number: NP_002043 View All» Gene Symbol:
  • GATA4

  • GATA-4
    View All» Alternate Names:
    • GATA binding protein 4

    • GATA-binding protein 4

    • GATA-binding factor 4

    • transcription factor GATA-4
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: Transcriptional activator. Binds to the consensus sequence 5'-AGATAG-3'. Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity).SUBUNIT STRUCTURE: Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1 (By similarity).SUBCELLULAR LOCATION: Nucleus. INVOLVEMENT IN DISEASE: Defects in GATA4 are the cause of atrial septal defect type 2 (ASD2) [MIM:607941]. ASD2 is a congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. ASD2 patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. ASD2 is not associated with defects in the cardiac conduction system or non-cardiac abnormalities. SEQUENCE SIMILARITIES: Contains 2 GATA-type zinc fingers. View All» Product Name: Anti-GATA-4, clone 13G4.2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://www.16ao.com/thread-131659.htm
        © Merck Millipore代理MAB4344 Anti-GATA-4, clone 13G4.2，产品报价联系微信jinshanbio