Merck Millipore代理04-260 19S Reg non-ATPase Subunit S14/Rpn12,mAb;已停产

2025-06-27

货号:04-260

品牌:Merck Millipore

规格:EA

目录价:询价

金山科研平台,产品价格货期咨询微信:jinshanbio Description: Anti-19S regulator non-ATPase subunit S14/Rpn12 Antibody, clone p31-27 | 04-260 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes 19S regulator non-ATPase subunit S14/Rpn12. View All» Molecular Weight: 30 kDa View All» Immunogen: Recombinant human Rpn12 protein. View All» Clone: p31-27 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Presentation: 100 µL of purified immunoglobulin in PBS containing 0.01M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4. View All» Storage Conditions: Stable for 1 year at -20°C from date of shipment for up to 12 months. View All» UniProt Number: P48556 View All» Entrez Gene Number: NM_002812.3 View All» Gene Symbol:

  • PSMD8

  • Nin1p

  • HYPF

  • HIP6

  • S14

  • MGC1660

  • p31

    View All» Alternate Names: S14; p31 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. View All» UniProt Summary: FUNCTION: SwissProt: P48556 # Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase.SIZE: 257 amino acids; 30005 Da SIMILARITY: SwissProt: P48556 ## Belongs to the proteasome subunit S14 family. View All» Brand Family: Upstate View All» Product Name: Anti-19S regulator non-ATPase subunit S14/Rpn12 Antibody, clone p31-27 | 04-260 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»

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