货号：MAB4350

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-BMP-7 Antibody, clone 2A10 | MAB4350 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This monoclonal antibody recognizes BMP-7. View All» Molecular Weight: 46 kDa View All» Immunogen: Recombinant full-length BMP-7 protein. View All» Clone: 2A10 View All» Isotype: IgG1κ View All» Background Information: Bone morphogenetic protein-7 (BMP-7), also known as osteogenic protein-1, is a member of the TGF- superfamily, and is widely expressed during embryonic development. Like other members of the bone morphogenetic protein family, BMP-7 works synergistically with BMP-2 to play a key role in the differentiation of mesenchymal cells into bone and cartilage tissues by actively recruiting stem cells from the surrounding tissue, thereby initiating the bone formation cascade. In adult cells, BMP-7 is predominately expressed in the brain, kidneys, and bladder. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Reacts with human and mouse. Reactivity with other species has not been tested. View All» Application Notes: Immunohistochemistry: Recommended working dilution is 1:50.Western Blotting: Recommended working concentration is 1 – 2 µg/mL. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl, and 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles. View All» UniProt Number: P18075 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry
    View All» UniProt Summary: Function Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.Subunit structure Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 By similarity.Subcellular location Secreted. Tissue specificity Expressed in the kidneys and bladder. Lower levels seen in the brain.Post-translational modification Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (Ref.5).Pharmaceutical use Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.Sequence similarities Belongs to the TGF-beta family. View All» Product Name: Anti-BMP-7, clone 2A10 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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