货号：MAB4358

品牌：Merck Millipore

规格：EA

目录价：￥3732.00

市场价格：￥3172.20

会员价格：￥2985.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ID2 Antibody, clone 10C5.2 | MAB4358 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 15 kDa View All» Immunogen: Recombinant GST Fusion protein (Human ID2) View All» Clone: 10C5.2 View All» Isotype: IgG3κ View All» Background Information: ID2 is an inhibitor of differentiation protein, which, along with ID1, ID3, and ID4, plays a key role in the regulation of lineage commitment, cell fate decisions, and in the timing of differentiation during neurogenesis, lymphopoiesis, and neovascularization (angiogenesis). Overexpression of ID2 has been shown to have profound effects on T-cell development and oncogenesis. The ID proteins, induced by the bone morphogenic protein-SMAD pathway, have also been shown to collaborate with LIF to ensure that embryonic stem cells opt for self-renewal. View All» Species Reactivity: Human View All» Presentation: Purified mouse monoclonal IgG3κ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8C in undiluted aliquots for up to 12 months. View All» UniProt Number: Q02363 View All» Entrez Gene Number: NM_002166 View All» Gene Symbol: ID2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunohistochemistry (Paraffin) View All» Entrez Gene Summary: The protein encoded by this gene belongs to the inhibitor of DNA binding (ID) family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the ID family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene has been identified for this gene. [provided by RefSeq] View All» UniProt Summary: FUNCTION: SwissProt: Q02363 # ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression.SIZE: 134 amino acids; 14917 Da SUBUNIT: Heterodimer with other HLH proteins.SUBCELLULAR LOCATION: Nucleus. View All» Product Name: Anti-ID2 Antibody, clone 10C5.2 | MAB4358 View All» Concentration: 0.41 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»