货号：MAB4369

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SRF [Serum Response Factor] Antibody, clone 1E1 | MAB4369 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This monoclonal antibody recognizes SRF. View All» Molecular Weight: ~52 kDa View All» Immunogen: Synthetic human SRF peptide, a.a. 406-508. View All» Clone: 1E1 View All» Isotype: IgG1κ View All» Background Information: Serum response factor (SRF) is a nuclear transcription factor that binds to the serum response element (SRE), and is essential for embryonic development of the mesoderm, as well as for the maintenance of adult muscle cells and neurons. As this protein is involved in the downstream regulation of many immediate-early genes, it participates in a variety of cell functions, including cell cycle, apoptosis, cell growth, and cell differentiation. SRF is most commonly activated by serum, LPA, LPS, TPA, growth factors, including TNFalpha, as well as antioxidants and UV light. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Reacts with human. A weak interaction with mouse has also been observed. Reactivity with other species has not been tested. View All» Application Notes: Immunocytochemistry: Recommended working dilution is 1:500. View All» Quality Assurance: (Based upon representative data from a previous lot).Western Blotting: Recommended working dilution is 0.5 µg/mL. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl, and 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles. View All» UniProt Number: P11831 View All» Entrez Gene Number: P11831 View All» Gene Symbol:
  • ELK3

  • ERP

  • MCM1

  • OTTHUMP00000039820

  • SAP2
    View All» Alternate Names: serum response factor (c-fos serum response element-binding transcription factor) View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» UniProt Summary: FUNCTION: SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentation and maturation.SUBUNIT STRUCTURE: Binds DNA as a multimer, probably a dimer. Interacts with MLLT7/FOXO4, NKX3A and SSRP1. Interacts with ARID2 and SRFBP1 By similarity. Forms complexes with ARID2, MYOCD, NKX2-5 and SRFBP1 By similarity.SUBCELLULAR LOCATION: Nucleus. PTM: Phosphorylated by PRKDC. SEQUENCE SIMILARITIES: Contains 1 MADS-box domain. View All» Product Name: Anti-SRF [Serum Response Factor], clone 1E1 View All» Concentration: 1E1 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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