货号：04-321

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-4E-BP1 Antibody, Rabbit | 04-321 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes the C-terminal domain of 4E-BP1. View All» Molecular Weight: 15-20 kDa View All» Immunogen: KLH-conjugated synthetic peptide corresponding to the C-terminal region of human 4E-BP1 (eIF4E-binding protein). View All» Isotype: IgG View All» Species Reactivity: Human View All» Species Reactivity Note: Not expected to react with mouse or rat. View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: 100 μL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide and 0.03% BSA and 40% glycerol. View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: Q13541 View All» Entrez Gene Number: NM_004095.3 View All» Gene Symbol:

• EIF4EBP1

• PHAS-I

• 4EBP1

• MGC4316

• 4E-BP1

• BP-1
  View All» Alternate Names: EIF4EBP1, eIF4E-binding protein 1, eukaryotic translation initiation factor 4E binding protein 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Western Blotting

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. View All» UniProt Summary: FUNCTION: SwissProt: Q13541 # Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.SIZE: 118 amino acids; 12580 Da SUBUNIT: Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Rapamycin can attenuate insulin stimulation, mediated by FKBPs.PTM: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: Q13541 ## Belongs to the eIF4E-binding protein family. View All» Brand Family: Upstate View All» Product Name: Anti-4E-BP1 Antibody, Rabbit | 04-321 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-131707.htm
    © Merck Millipore代理04-321 anti-4E-BP1, rabbit mono;已停产，产品报价联系微信jinshanbio