货号：MAB4399

品牌：Merck Millipore

规格：EA

目录价：￥4000.00

市场价格：￥3400.00

会员价格：￥3200.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CD133 (Prominin-1) Antibody, clone 17A6.1 | MAB4399 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~97 kDa observed. CD133 has multiple isoforms ranging from 92 kDa to 97 kDa. View All» Immunogen: Recombinant protein corresponding to human CD133 (Prominin-1). View All» Clone: 17A6.1 View All» Isotype: IgG2aκ View All» Background Information: CD133 (Prominin-1) belongs to a family of cell-surface glycoproteins harboring five transmembrane domains, and is found in both normal cells and in several tumor and cancer cell types. In epithelial cells, particularly neuroepithelial stem cells, CD133 was found in the microvilli, primary cilium, and midbody. These three types of apical membrane protrusions are subject to remodeling during epithelial and neuroepithelial cell differentiation. CD133 may play a key role in apical plasma membrane organization in epithelial cells. CD133 acts a regulator of disk morphogenesis in early retinal development and also suppresses cell differentiation in a RET-dependent manner in neuroblastoma cells. Overexpression of this glycoprotein has been reported in acute myelogenous leukaemia, acute lymphocytic leukaemia, chronic lymphocytic leukaemia, myelodysplastic syndromes, retinoblastomas, glioblastomas and kidney carcinomas. High levels of CD133 were also found in pancreatic, gastric, colorectal, and hepatocellular cancers. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected CD133 (Prominin-1) in human glioblastoma cells. View All» Control: Recombinant CD133 (Prominin-1). View All» Quality Assurance: Evaluated by Western Blot in CD133 (Prominin-1) recombinant protein.Western Blot Analysis: 0.2 µg/mL of this antibody detected CD133 (Prominin-1) in 2.5 µg of recombinant CD133 (Prominin-1). View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O43490 View All» Entrez Gene Number: NP_001139319 View All» Gene Symbol:

• PROM1

• PROML1

• MSTP061
  View All» Alternate Names:
  • Prominin-1

  • Antigen AC133

  • Prominin-like protein 1

  • CD133
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes a pentaspan transmembrane glycoprotein. The protein localizes to membrane protrusions and is often expressed on adult stem cells, where it is thought to function in maintaining stem cell properties by suppressing differentiation. Mutations in this gene have been shown to result in retinitis pigmentosa and Stargardt disease. Expression of this gene is also associated with several types of cancer. This gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Multiple transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: Binds cholesterol in cholesterol-containing plasma membrane microdomains. Proposed to play a role in apical plasma membrane organization of epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.SUBUNIT STRUCTURE: Interacts with CDHR1 and with actin filaments.SUBCELLULAR LOCATION: Cell projection > cilium > photoreceptor outer segment. Isoform 1: Apical cell membrane; Multi-pass membrane protein. Cell projection > microvillus membrane; Multi-pass membrane protein. Note: Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.TISSUE SPECIFICITY: Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, skeletal muscle, kidney, and heart as well as adult pancreas, kidney, liver, lung, and placenta. Isoform 2 is highly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level). View All» Product Name: Anti-CD133 (Prominin-1), clone 17A6.1 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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