货号：MAB443

品牌：Merck Millipore

规格：100UL

目录价：￥4239.00

市场价格：￥3603.15

会员价格：￥3391.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Estrogen Receptor Antibody, a.a. 120-170, clone AER304 | MAB443 View All» Replaces: CBL425 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Estrogen receptor 67kD hormone binding subunit. Epitope localized between aa 120-170. View All» Epitope: a.a. 120-170 View All» Immunogen: Bovine estrogen receptor. View All» Clone: AER304 View All» Isotype: IgG1 View All» Species Reactivity:

• Bovine

• Chicken

• Human

• Mouse
  View All» Application Notes: Western blot (human) Immunoprecipitation (human) Immunohistochemistry (mouse) Optimal working dilutions must be determined by the end user. View All» Presentation: Liquid View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to one year. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P03372 View All» Entrez Gene Number: NM_000125.2 View All» Gene Symbol:
  • ESR1

  • ER-alpha

  • ESR

  • Era

  • ER

  • NR3A1

  • ESRA

  • DKFZp686N23123
    View All» Alternate Names: ER View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. View All» Key Applications:
    • Electrophoretic Mobility Shift Assay

    • Immunoprecipitation

    • Western Blotting

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION: SwissProt: P03372 # Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.SIZE: 595 amino acids; 66216 Da SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with JARID1A. Interacts with SMARD1. Interacts with SLC30A9 (By similarity). Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1.SUBCELLULAR LOCATION: Nucleus.DOMAIN: SwissProt: P03372 Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.PTM: Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. & Contains 1 nuclear receptor DNA-binding domain.MISCELLANEOUS: In the absence of ligand, steroid hormone receptors are thought to be weakly associated with nuclear components; hormone binding greatly increases receptor affinity. The hormone- receptor complex appears to recognize discrete DNA sequences upstream of transcriptional start sites. View All» Brand Family: Chemicon View All» Product Name: Anti-Estrogen Receptor Antibody, a.a. 120-170, clone AER304 | MAB443 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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