货号：MAB4500

品牌：Merck Millipore

规格：100Ug

目录价：￥4167.00

市场价格：￥3541.95

会员价格：￥3333.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-B23 Antibody, clone 3C9 | MAB4500 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes human Nucleophosmin (B23). View All» Immunogen: Total extracts of Daudi cell nuclei. View All» Clone: 3C9 View All» Isotype: IgM View All» Background Information: B23/Nucleophosmin is a major nucleolar phosphoprotein that is mainly located within the nucleolar granular compartment, where preribosomes are assembled. B23/Nucleophosmin is a multifunctional protein that is overexpressed in actively proliferating cells and cancer cells. Antibodies against B23 might be useful for recognition of human peripheral lymphocytes at early stages of their activation for proliferation, preceding the S-phase (Dergunova, 2002). By parallel immunolabeling with the anti-Ki-67 antibody, it was shown that the early changes of B23 amount and localization occurred before an appearance of Ki-67 protein, a well-known marker of proliferating cells (Dergunova, 2002). View All» Species Reactivity: Human View All» Application Notes: Western blot Immunocytochemistry Immunoprecipitation Optimal working dilutions must be determined by end user. View All» Presentation: 0.05M Potassium phosphate, 0.3M Sodium chloride, and 0.05% Sodium azide View All» Storage Conditions: Maintain at 2-8°C for up 12 months from date of receipt. View All» UniProt Number: P06748 View All» Entrez Gene Number:

• NM_001037738.1

• NM_002520.5

• NM_199185.2
  View All» Gene Symbol:
  • NPM1

  • Numatrin

  • numatrin

  • Nucleophosmin

  • MGC104254

  • NPM

  • B23
    View All» Alternate Names: Nucleophosmin View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunofluorescence

    • Immunoprecipitation

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P06748 # Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. It may function in the assembly and/or transport of ribosome.SIZE: 294 amino acids; 32575 Da SUBUNIT: Disulfide-linked dimers under certain conditions. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70 (By similarity). Interacts with NSUN2.SUBCELLULAR LOCATION: Nucleus, nucleolus. Note=Generally nucleolar, but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML), but not with secondary AML.PTM: Phosphorylated.DISEASE: SwissProt: P06748 # A chromosomal aberration involving NPM1 is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with ALK. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. & A chromosomal aberration involving NPM1 is found in a form of acute promyelocytic leukemia. Translocation t(5;17)(q32;q11) with RARA. & A chromosomal aberration involving NPM1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with MLF1. & Defects in NPM1 are associated with acute myelogenous leukemia (AML). Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location.SIMILARITY: SwissProt: P06748 ## Belongs to the nucleoplasmin family. View All» Brand Family: Chemicon View All» Product Name: Anti-B23 Antibody, clone 3C9 | MAB4500 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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