货号：04-387

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TBK1/NAK (N-term) Antibody, clone EP611Y, Rabbit Monoclonal | 04-387 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminus of TBK1/NAK. View All» Molecular Weight: ~84 kDa observed View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to the N-terminus of human TBK1/NAK. View All» Clone: EP611Y View All» Isotype: IgG View All» Background Information: NFkappaB-activating kinase (NAK) also known as TANK binding kinase-1 (TBK1) or tumor necrosis factor receptor associated factor 2-associated kinase (T2K) is a serine/threonine protein that belongs to the IkB kinase (IKK) family (1). Similar to IKK alpha and beta (2), NAK induces IkB degradation and NF-kB activity. NAK is activated by phorbol ester tumor promoters and growth factors, whereas catalytically inactive NAK specifically inhibits activation of NF-kB by protein kinase C-epsilon (PKCepsilon). NAK specifically phosphorylates IkB alpha on Serine 36 and NFkB subunit RelA (p65) on Serine 536 (3). NAK is also known to interact with TANK, TRAF-2 and TRIF (4). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse and Rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:50 dilution from a representative lot was used in human breast carcinoma tissue.Immunocytochemistry Analysis: A 1:250-500 dilution from a representative lot was used in IC.Immunoprecipitation Analysis: A 1:10-100 dilution from a representative lot was used in IP. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysateWesternBlot Analysis: A 1:1,000 dilution of this antibody detected TBK1/NAK in HeLa cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing glycerol, BSA, and sodium azide. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q9UHD2 View All» Entrez Gene Number: Q9UHD2 View All» Gene Symbol:
  • NAK

  • T2K

  • FLJ11330

  • OTTHUMP00000239491

  • EC 2.7.11.1

  • EC 2.7.11
    View All» Alternate Names:
    • TANK-binding kinase 1

    • NF-kappa-B-activating kinase

    • NF-kB-activating kinase

    • serine/threonine-protein kinase TBK1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry

      • Immunoprecipitation

      • Immunohistochemistry (Paraffin)
        View All» Product Name: Anti-TBK1/NAK (N-term), clone EP611Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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