货号：MAB4602

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Mcl-1, clone RC13 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Recognizes a 42 kD protein identified as Myeloid cell leukemia-1 (Mcl-1), a member of the bcl-2 family which is expressed in ML-1 cells during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Expression of Mcl-1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents, along with an increase in Bax and a decrease in bcl-2. Enhanced expression of Mcl-1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation. Like bcl-2, Mcl-1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis. View All» Immunogen: Recombinant human Mcl-1 protein corresponding to aa 1-327. View All» Clone: RC13 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Application Notes: Western blot: 1 μg/ml for 2 hours at RT Immunoprecipitation (use protein G): 2 μg/mg of protein lysate Immunohistochemistry (frozen and paraffin): 2-4 μg/ml for 30 minutes at RT (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min. followed by cooling for 20 min. at RT) Optimal working dilutions must be determined by end user. View All» Presentation: Liquid in 10 mM PBS, pH 7.4, with 0.2% BSA and 15 mM sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. View All» UniProt Number: Q07820 View All» Entrez Gene Number:

• NM_021960.3

• NM_182763.1
  View All» Gene Symbol:
  • MCL1

  • MCL1L

  • mcl1/EAT

  • MGC1839

  • MGC104264

  • TM

  • MCL1S

  • EAT
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. View All» UniProt Summary: FUNCTION: SwissProt: Q07820 # Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis while isoform 2 promotes it.SIZE: 350 amino acids; 37337 Da SUBUNIT: Interacts with BAD, BOK, BIK, BFM and PMAIP (By similarity). Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro- apoptototic BCL2-related proteins.SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.PTM: Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment. & Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. & Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.SIMILARITY: SwissProt: Q07820 ## Belongs to the Bcl-2 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Mcl-1, clone RC13 View All» Concentration: 0.2 mg/ml View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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