货号：04-393

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit | 04-393 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes the p70 S6 Kinase when phosphorylated on Thr421 and Ser424. View All» Molecular Weight: 70 kDa View All» Immunogen: KLH-conjugated synthetic peptide corresponding to the region surrounding Thr421 and Ser424 of human p70 S6 Kinase. View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity: Human View All» Species Reactivity Note: Not believed to react with mouse or rat. View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: 100 μL of rabbit monoclonal IgG in 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol. View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: P23443 View All» Entrez Gene Number: NM_003161.2 View All» Gene Symbol:

• RPS6KB1

• p70-alpha

• p70S6k

• p70-S6K

• p70

• S6K

• S6Kalpha)

• P70S6K

• STK14A

• S6K1

• p70(S6K)-alpha

• PS6K
  View All» Alternate Names: RPS6KB1 ribosomal protein S6 kinase, 70kDa, PS6K, S6K, S6K1, STK14A, p70(S6K)-alpha, p70-S6K, p70-alpha View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines. Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized. View All» UniProt Summary: FUNCTION: SwissProt: P23443 # Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens.SIZE: 525 amino acids; 59140 Da SUBUNIT: Interacts with PPP1R9A/neurabin-1 (By similarity).SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, synaptosome (By similarity).TISSUE SPECIFICITY: Widely expressed.SIMILARITY: SwissProt: P23443 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-p70 S6 Kinase (Thr421/Ser424) Antibody, rabbit | 04-393 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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