货号：04-395

品牌：Merck Millipore

规格：

目录价：￥3697.00

市场价格：￥3142.45

会员价格：￥2957.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PAK3 Antibody, rabbit | 04-395 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes the N-terminus of PAK3. View All» Molecular Weight: 65 kDa View All» Immunogen: KLH-conjugated synthetic peptide corresponding to N-terminus of human PAK3 (p21-Activated Kinase 3). View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: 100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol. View All» UniProt Number: O75914 View All» Entrez Gene Number: NM_002578.2 View All» Gene Symbol:
  • PAK3

  • OPHN3

  • PAK3beta

  • OTTHUMP00000062894

  • hPAK3

  • MRX47

  • MRX30

  • bPAK

  • oligophrenin-3

  • CDKN1A

  • PAK-3

  • Beta-PAK

  • Oligophrenin-3
    View All» Alternate Names: p21-activated Kinase 3, p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related) View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunofluorescence

    • Immunoprecipitation

    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. A point mutation in this gene has been linked to nonsyndromic X-linked mental retardation. View All» UniProt Summary: FUNCTION: SwissProt: O75914 # Key regulator of synapse formation and plasticity in the hippocampus (By similarity).COFACTOR: Magnesium (By similarity).SIZE: 559 amino acids; 62310 Da SUBUNIT: Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK.TISSUE SPECIFICITY: Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.PTM: Autophosphorylated when activated by CDC42/p21.DISEASE: SwissProt: O75914 # Defects in PAK3 are the cause of non-syndromic mental retardation X-linked type 30 (MRX30) [MIM:300558]; also called X- linked mental retardation type 47 (MRX47). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs.SIMILARITY: SwissProt: O75914 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-PAK3 Antibody, rabbit | 04-395 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-131786.htm
      © Merck Millipore代理04-395 anti-PAK3，产品报价联系微信jinshanbio