货号：MAB463

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Estrogen Receptor Antibody, a.a. 151-165, clone B10 | MAB463 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The peptide used as the immunogen for this product correspond to the amino-acid sequence 151-165 from human ER alpha receptor. By IP, western, gel retardation and ELISA assays clone B10 do not react with other nuclear receptors. SPECIES REACTIVITIES: Does not cross react with chicken ER. Other reactivities have not been evaluated. By sequence homology pig ER is 100% identical, rat is 80% conserved. View All» Epitope: a.a. 151-165 View All» Clone: B10 View All» Isotype: IgG2a View All» Species Reactivity:

• Human

• Rat
  View All» Application Notes: Immunohistochemistry (frozen sections, microwave oven treated paraffin sections) at 1:1,000-1:2,000 Immunocytochemistry (formaldehyde fixation) at 1:1,000-1:2,000 ELISA at 1:1,000-1:2,000 Western blot analysis at 1:1,000-1:2,000 Immunoprecipitation at 1:1-1:10 Gel super shifts at 1:1-1:10 Optimal working dilutions must be determined by the end user. View All» Presentation: Ascites. Liquid, does not contain any preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots up to 12 months. Avoid repeated freeze/thaw cycles. View All» UniProt Number: P98160 View All» Entrez Gene Number: NM_005529.5 View All» Gene Symbol:
  • HSPG2

  • SJA

  • perlecan

  • SJS

  • HSPG

  • PRCAN

  • Perlecan

  • SJS1

  • PLC
    View All» Alternate Names: ER View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: Heparan sulfate proteoglycan is a major component of basement membranes, where the molecule may be involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. This form of HSPG, known as HSPG2 or perlecan, is encoded by a gene that maps to chromosome 1. The gene for the form of HSPG associated with the cell surface of fibroblasts has been mapped to human chromosome 8 (MIM 142460).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P98160 # This protein is an integral component of basement membranes. It is responsible for the fixed negative electrostatic charge and is involved in the charge-selective ultrafiltration properties. It serves as an attachment substrate for cells.SIZE: 4391 amino acids; 468825 Da SUBUNIT: Purified perlecan has a strong tendency to aggregate in dimers or stellate structures. It interacts with other basement membrane components such as laminin, prolargin and collagen type IV. Interacts with COL13A1, FGFBP1 and VWA1.SUBCELLULAR LOCATION: Secreted, extracellular space.TISSUE SPECIFICITY: Found in the basement membranes.PTM: N- and O-glycosylated; contains three heparan sulfate chains.DISEASE: SwissProt: P98160 # Defects in HSPG2 are the cause of Schwartz-Jampel syndrome (SJS1) [MIM:255800]; a rare autosomal recessive disorder characterized by permanent myotonia (prolonged failure of muscle relaxation) and skeletal dysplasia, resulting in reduced stature, kyphoscoliosis, bowing of the diaphyses and irregular epiphyses. & Defects in HSPG2 are the cause of dyssegmental dysplasia Silverman-Handmaker type (DDSH) [MIM:224410]. The dyssegmental dysplasias are rare, autosomal recessive skeletal dysplasias with anisospondyly and micromelia. There are two recognized types: the severe, lethal DDSH and the milder Rolland-Desbuquois form. Individuals with DDSH also have a flat face, micrognathia, cleft palate and reduced joint mobility, and frequently have an encephalocoele. The endochondral growth plate is short, the calcospherites (which are spherical calcium-phosphorus crystals produced by hypertrophic chondrocytes) are unfused, and there is mucoid degeneration of the resting cartilage.SIMILARITY: SwissProt: P98160 ## Contains 4 EGF-like domains. & Contains 22 Ig-like C2-type (immunoglobulin-like) domains. & Contains 11 laminin EGF-like domains. & Contains 3 laminin G-like domains. & Contains 3 laminin IV type A domains. & Contains 4 LDL-receptor class A domains. & Contains 1 SEA domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Estrogen Receptor Antibody, a.a. 151-165, clone B10 | MAB463 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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