货号：04-404

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-PKA Antibody, RII (Ser96), Rabbit | 04-404 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes PKA, RII only when phosphorylated on Ser96. View All» Molecular Weight: 51 kDa View All» Immunogen: KLH-conjugated synthetic peptide corresponding to the amino acids surrounding Ser 96 of human PKA, RII. View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: 100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide and 0.03% BSA with 40% glycerol. View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: P13861 View All» Entrez Gene Number: NM_004157.2 View All» Gene Symbol:
  • PRKAR2A

  • MGC3606

  • PKR2

  • PRKAR2
    View All» Alternate Names: PRKAR2A, protein kinase, cAMP-dependent, regulatory, type II, alpha View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunofluorescence

    • Immunoprecipitation

    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). View All» UniProt Summary: FUNCTION: SwissProt: P13861 # Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.SIZE: 404 amino acids; 45518 Da SUBUNIT: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4 and CBFA2T3.TISSUE SPECIFICITY: Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.PTM: Phosphorylated by the activated catalytic chain.SIMILARITY: SwissProt: P13861 ## Belongs to the cAMP-dependent kinase regulatory chain family. & Contains 2 cyclic nucleotide-binding domains. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-PKA Antibody, RII (Ser96), Rabbit | 04-404 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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