货号：04-433

品牌：Merck Millipore

规格：

目录价：￥4528.00

市场价格：￥3848.80

会员价格：￥3622.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bak Antibody, Rabbit | 04-433 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes a region near the N-terminus domain of human Bak. View All» Molecular Weight: ~23 kDa View All» Immunogen: KLH-conjugated synthetic peptide corresponding to the N-terminal region of human Bak. View All» Isotype: IgG View All» Species Reactivity: Human Only View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol. View All» Storage Conditions: 2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage. View All» UniProt Number: Q16611 View All» Entrez Gene Number: NM_001188.3 View All» Gene Symbol:

• BAK1

• CDN1

• BAK

• BAK-LIKE

• MGC3887

• BCL2L7

• OTTHUMP00000039620

• MGC117255
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Flow Cytometry

  • Immunofluorescence

  • Western Blotting

  • Immunohistochemistry (Paraffin)
    View All» Entrez Gene Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. View All» UniProt Summary: FUNCTION: SwissProt: Q16611 # In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the a repressor Bcl-2 or its adenovirus homolog E1B 19k protein.SIZE: 211 amino acids; 23409 Da SUBUNIT: Forms heterodimers with Bcl-2, E1B 19k protein, and Bcl- X(L).SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).TISSUE SPECIFICITY: Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.DOMAIN:SwissProt: Q16611 Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.SIMILARITY: Belongs to the Bcl-2 family. View All» Brand Family: Upstate View All» Product Name: Anti-Bak Antibody, Rabbit | 04-433 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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