货号：04-437

品牌：Merck Millipore

规格：

目录价：￥4376.00

市场价格：￥3719.60

会员价格：￥3500.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bcl-6 (C-term) Antibody, Rabbit | 04-437 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes a region near the C-terminus of human Bcl-6. View All» Molecular Weight: 87-98 kDa View All» Immunogen: KLH-conjugated synthetic peptide near the C-terminus of human Bcl-6. View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol. View All» Storage Conditions: 2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage. View All» UniProt Number: P41182 View All» Entrez Gene Number:

• NM_001706.2

• NM_138931.1
  View All» Gene Symbol:
  • BCL6

  • ZBTB27

  • BCL-5

  • ZNF51

  • BCL-6

  • LAZ3

  • BCL6A

  • BCL5
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunofluorescence

    • Immunoprecipitation

    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. View All» UniProt Summary: FUNCTION: SwissProt: P41182 # Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.SIZE: 706 amino acids; 78846 Da SUBUNIT: Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.SUBCELLULAR LOCATION: Nucleus (By similarity).TISSUE SPECIFICITY: Expressed in germinal center T and B cells and in primary immature dendritic cells.PTM: Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.DISEASE: SwissProt: P41182 # Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. & A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. & A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.SIMILARITY: SwissProt: P41182 ## Contains 1 BTB (POZ) domain. & Contains 6 C2H2-type zinc fingers. View All» Brand Family: Upstate View All» Product Name: Anti-Bcl-6 (C-term) Antibody, Rabbit | 04-437 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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