货号：MAB5258-50UG

品牌：Merck Millipore

规格：EA

目录价：￥5020.00

市场价格：￥4267.00

会员价格：￥4016.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Synaptophysin Antibody, clone SY38 | MAB5258-50UG View All» Replaces: CBL203 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody reacts with presynaptic vesicles of cerebral and spinal neurons, of neuromuscular endplates and with the retina of man, cow, rat and mouse. The antibody also reacts with vesicles of adrenal medulla and islet cells, and additionally allows specific staining of neuronal, adrenal and neuroepithelial tumors, such as pheochromocytoma, paraganglioma, islet cell tumors (incl. Insulinoma), medullary thyroid carcinoma and diverse pulmonary and gastro-intestinal carcinoids. The antibody also stains neurosecretory vesicles of certain culture cells, e.g. of the rat cell line PC-12. View All» Molecular Weight: 38 kDa View All» Immunogen: Vesicular fraction of bovine brain View All» Clone: clone SY38) View All» Isotype: IgG1κ View All» Background Information: Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38 kDa. It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. The localization and ubiquitous expression of this protein in neuronal tissue makes it an excellent marker for neurons and neuroendocrine tumors. The gene for this protein is located on the X chromosome (Xp11.23-p11.22). The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine

• Avian

• Fish
  View All» Application Notes: Immunohistochemistry: For relatively cytoplasm rich neuroendocrinic tumors a final concentration of 1 μg/mL is recommended. A final concentration of 2 μg/mL is recommended for cytoplasm deficient tumors.Optimal working dilutions must be determined by end user. View All» Control: Positive Control: PancreasNegative Control: Normal mouse serum View All» Quality Assurance: Evaluated by Western Blot on mouse brain lysates.Western Blot Analysis: 1:1000 dilution of this antibody detected synaptophysin on 10 ug of mouse brain lysates. View All» Purification Method: Protein A purfied View All» Presentation: Purified mouse monoclonal IgG1κ liquid in buffer containing 20 mM sodium phosphate buffer, 5 mg/mL BSA, with 0.01% methylisothiazolone MIT (w/v), pH 7.5. View All» Storage Conditions: Stable for 1 year at from date of receipt. View All» UniProt Number: P08247 View All» Entrez Gene Number: NM_003179.2 View All» Gene Symbol:
  • SYP

  • synaptophysin

  • Synaptophysin
    View All» Alternate Names: Major synaptic vesicle protein p38 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry
      View All» Entrez Gene Summary: Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P08247 # Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.SIZE: 313 amino acids; 33845 Da SUBUNIT: Homohexamer or homotetramer.SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.DOMAIN: SwissProt: P08247 The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (By similarity).SIMILARITY: Belongs to the synaptophysin/synaptobrevin family. & Contains 1 MARVEL domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Synaptophysin Antibody, clone SY38 | MAB5258-50UG View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Purified View All» Host: Mouse View All»
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