货号：MAB5276

品牌：Merck Millipore

规格：40Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Endorphin Antibody, β, clone 3-E7 | MAB5276 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: The antibody reacts with the amino terminal H-Tyr-Gly-Gly-Phe sequence of human O-endorphin. Therefore, a high cross-reactivity with homologues of identical sequence, such as [Met]-enkephalin and [Leu]-enkephalin and a number of opioid peptides, occurs; the antibody also reacts with swine and camel O-endorphin. However, the antibody does not recognize human beta-lipotropin and N-acetyl-beta-endorphin (Gramsch et al., 1983; Meo et al., 1983; Herz et al., 1982). View All» Immunogen: Synthetic human beta-endorphin coupled with poly-lysine or thyroglobulin (Gramsch et al., 1983; Meo et al., 1983) (H-Tyr-Gly-Gly-Phe sequence). View All» Clone: 3-E7 View All» Isotype: IgG2a View All» Species Reactivity:

• Human

• Pig
  View All» Application Notes: ELISA Immunohistochemistry Optimal working dilutions must be determined by end user. View All» Presentation: Purified immunoglobulin. Liquid in 0.02M Phosphate buffer with 0.25M NaCl and 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: P01189 View All» Entrez Gene Number:
  • NM_000939.2

  • NM_001035256.1
    View All» Gene Symbol:
    • POMC

    • pro-ACTH-endorphin

    • adrenocorticotropin

    • beta-LPH

    • POC

    • gamma-LPH

    • LPH

    • beta-endorphin

    • corticotropin

    • ACTH

    • alpha-MSH

    • beta-MSH

    • pro-opiomelanocortin

    • proopiomelanocortin

    • Pro-opiomelanocortin

    • NPP

    • corticotropin-lipotrophin

    • MSH

    • met-enkephalin

    • CLIP

    • gamma-MSH
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • ELISA

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. View All» UniProt Summary: FUNCTION: SwissProt: P01189 # Beta-endorphin and Met-enkephalin are endogenous opiates.SIZE: 267 amino acids; 29424 Da TISSUE SPECIFICITY: ACTH and MSH are produced by the pituitary gland.PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides. & O-glycosylated; reducing sugar is probably N- acetylgalactosamine.DISEASE: SwissProt: P01189 # Defects in POMC may be associated with susceptibility to obesity [MIM:601665]. & Defects in POMC are the cause of pro-opiomelanocortinin deficiency [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.SIMILARITY: SwissProt: P01189 ## Belongs to the POMC family. View All» Brand Family: Chemicon View All» Product Name: Anti-Endorphin Antibody, β, clone 3-E7 | MAB5276 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 40 µg View All» Format: Purified View All» Host: Mouse View All»
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