货号：MAB5280

品牌：Merck Millipore

规格：40Ug

目录价：￥6588.00

市场价格：￥5599.80

会员价格：￥5270.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tyrosine Hydroxylase Antibody, clone 2/40/15 | MAB5280 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Tyrosine hydroxylase (TH) catalyzes the rate-determining initial step in the biosynthesis of catecholamines such as dopamine, noradrenaline and adrenaline. Therefore the antibody is used to stain dopaminergeous and adrenergeous neurons as well as the chromaffine tissue of the adrenal medulla. Cell lines such as the PC 12 line, which is derived from a rat pheochromocytoma also, show positive reactions. In immunoblots of adrenal medulla tissue, the antibody recognizes a single protein band in the molecular weight range of 56 - 60 kD. View All» Molecular Weight: 56-60 kDa View All» Immunogen: Purified tyrosine hydroxylase (EC 1.14.16.2) from a rat pheochromocytoma (2). View All» Clone: 2/40/15 View All» Isotype: IgG2a View All» Background Information: Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing. View All» Species Reactivity:

• Bovine

• Chicken

• Quail

• Rat
  View All» Application Notes: Immunohistochemistry: 1:100-1:500. A previous lot of this antibody was used in immunohistochemistry.Western blot:1:1000-1:2000 Optimal working dilutions must be determined by end user. View All» Control: Positive Control: Brain (sympathetic nerve terminals) and adrenal gland tissue View All» Quality Assurance: Routinely evaluated by Western Blot on PC12 lysates.Western Blot Analysis: 1:1000 dilution of this lot detected Tyrosine Hydroxylase on 10 μg of PC12 lysates. View All» Purification Method: Protein A purfied View All» Presentation: Purified mouse monoclonal IgG2a in buffer containing 0.02 M Phosphate buffer, 0.25 M NaCl, pH 7.6 with 0.1% sodium azide. View All» Storage Conditions: Stable for 6 months at 2-8ºC in undiluted aliquots from date of receipt. View All» UniProt Number: P07101 View All» Entrez Gene Number: NM_000360.3 View All» Gene Symbol:
  • TH

  • TYH

  • EC 1.14.16.2
    View All» Alternate Names: TH; Tyrosine Monooxygenase View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. View All» UniProt Summary: FUNCTION: SwissProt: P07101 # Plays an important role in the physiology of adrenergic neurons.COFACTOR: Fe(2+) ion.SIZE: 528 amino acids; 58524 Da TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.DISEASE: SwissProt: P07101 # Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.SIMILARITY: SwissProt: P07101 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. View All» Brand Family: Chemicon View All» Product Name: Anti-Tyrosine Hydroxylase Antibody, clone 2/40/15 | MAB5280 View All» Concentration: 1 .0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 40 µg View All» Target / Localization: Cytoplasmic View All» Format: Purified View All» Host: Mouse View All»
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