货号：MAB5284

品牌：Merck Millipore

规格：100Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Chondroitin sulfate proteoglycan (CSPG), brain core protein. View All» Epitope: Brain (core protein) View All» Immunogen: Feline spinal cord fixed gray matter. View All» Clone: Cat-301 View All» Isotype: IgG1 View All» Background Information: The antigen recognized by this clone, CAT-301 is a proteoglycan that is developmentaly regulated, high molecular chondroitin sulphate proteoglycan found on the extracellular surface of mammalian neurons. It is expressed late in development and although no definitive role has been identified for CAT-301, it is believed to have a role in the stabilisation of synaptic structure. The name derives from the name of the monoclonal antibody originally used to identified by its expression, which was detected immunocytochemicaly Disruption of the normal patterns of neuronal activity during the critical early postnatal period by physical or biochemical means results in a large and irreversible reduction in levels of CAT-301. Similar intervention in mature animals has no effect CAT-301 is related to aggrecan from articular cartilage. The CAT-301 antibody immunoreacts with aggrecan, and the chondroitinase treated aggrecan and CAT-301 both have apparent sizes of 550kDa. However CAT- 301 is not glycosylated by keratan sulphate, as aggrecan is. View All» Species Reactivity:

• Guinea Pig

• Human

• Hamster

• Rat

• Feline

• Gerbil

• Primate
  View All» Application Notes: Immunohistochemistry: 1:500-1:2,000 on 4% paraformaldehyde fixed frozen tissue. Immunocytochemistry Immunoblot Immunoprecipitation Optimal working dilutions must be determined by the end user. View All» Presentation: Purified immunoglobulin. Liquid. Buffer = 0.02M Phosphate buffer, 0.25M NaCl, pH 7.6 with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: P16112 View All» Entrez Gene Number:
  • NM_001135.2

  • NM_013227.2
    View All» Gene Symbol:
    • ACAN

    • MSK16

    • SEDK

    • CSPCP

    • AGCAN

    • AGC1

    • CSPG1

    • CSPGCP
      View All» Alternate Names: CSPG View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. View All» UniProt Summary: FUNCTION: SwissProt: P16112 # This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.SIZE: 2415 amino acids; 250193 Da SUBUNIT: Interacts with FBLN1 (By similarity).SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).TISSUE SPECIFICITY: Restricted to cartilages.DEVELOPMENTAL STAGE: Expression was detected in chondrocytes throughout the developing skeleton.DOMAIN: SwissProt: P16112 Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.PTM: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase.DISEASE: SwissProt: P16112 # Defects in AGC1 are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) [MIM:608361]. Spondyloepiphyseal dysplasias are a heterogeneous group of congenital chondrodysplasias that specifically affect epiphyses and vertebrae. The autosomal dominant SEDK is associated with premature degenerative arthropathy.SIMILARITY: Belongs to the aggrecan/versican proteoglycan family. & Contains 1 C-type lectin domain. & Contains 1 EGF-like domain. & Contains 1 Ig-like V-type (immunoglobulin-like) domain. & Contains 4 Link domains. & Contains 1 Sushi (CCP/SCR) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-Chondroitin Sulfate Proteoglycan Antibody, Brain (core protein), clone Cat-301 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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