货号：04-539

品牌：Merck Millipore

规格：200Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MAPKAP-K2 Antibody, clone 7H4.2 | 04-539 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Molecular Weight: 45 kDa View All» Immunogen: KLH-conjugated synthetic peptide of the C-terminus of the long form of human MAPKAP-K2. View All» Clone: 7H4.2 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Suggested dilutions: Immunoblot Analysis: 1:500 Immunoprecipitation: 1:20 View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Protein A purfied View All» Presentation: 200 µg (1 mg/mL) of mouse monoclonal IgG in PBS containing 0.1% sodium azide. View All» Storage Conditions: 2 years at -20°C from date of shipment. View All» UniProt Number: P49137 View All» Entrez Gene Number:
  • NM_004759.3

  • NM_032960.2
    View All» Gene Symbol:
    • MAPKAPK2

    • MK2

    • MAPKAPK-2
      View All» Alternate Names: MAPK-activated protein kinase 2, MAPKAP kinase 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P49137 # Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue (By similarity). Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity.SIZE: 400 amino acids; 45568 Da SUBUNIT: Interacts with PHC2.TISSUE SPECIFICITY: Expressed in all tissues examined.PTM: Phosphorylated and activated by MAP kinase.SIMILARITY: SwissProt: P49137 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-MAPKAP-K2 Antibody, clone 7H4.2 | 04-539 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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