货号：04-565

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Caveolin-1 Antibody, clone E249, Rabbit | 04-565 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminus of Caveolin-1. The antibody should recognize both alpha and beta forms of Caveolin-1. View All» Molecular Weight: 22 kDa calculated View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to the C-terminus of human Caveolin-1. View All» Isotype: IgG View All» Background Information: Caveolins make up a family of proteins that are principal structural components of hairpin-like domains in the plasma membrane (1). It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Three members of caveolins (caveolin-1, -2 and -3) have been identified, possessing different tissue distributions (2). Caveolins interact with multiple signaling molecules, such as the G-protein alpha subunit (1), tyrosine kinase receptors, PKCs, Src family tyrosine kinases and eNOS (2,3). Caveolin-1 has been implicated in the pathogenesis of mammary epithelial cell hyperplasia (4). View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunohistochemistry Analysis: A 1:250 dilution from a representative lot was used in human lung tissue.Immunocytochemistry Analysis: A 1:100 dilution from a representative lot was used in IC.Western Blot Analysis: A 1:1,000-10,000 dilution from a representative lot was used in WB. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Immunohistochemistry in human urinary bladder tissue.Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Caveolin-1 in human urinary bladder tissue View All» Purification Method: Unpurified View All» Presentation: This antibody recognizes the C-terminus of Caveolin-1. The antibody should recognize both alpha and beta forms of Caveolin-1. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q03135 View All» Entrez Gene Number: Q03135 View All» Gene Symbol:

• BSCL3

• CGL3

• MSTP085

• OTTHUMP00000025031

• OTTHUMP00000195988

• OTTHUMP00000195989

• OTTHUMP00000196475

• OTTHUMP00000198308

• VIP21

• caveolin-1

• CAV
  View All» Alternate Names:
  • caveolin 1, caveolae protein, 22kDa

  • caveolin 1, caveolae protein, 22kD

  • cell growth-inhibiting protein 32
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)
      View All» UniProt Summary: FUNCTION: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity By similarity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. SUBUNIT STRUCTURE: Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP By similarity. Interacts with BMX and BTK.SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane › caveola; Peripheral membrane protein. Membrane raft. Note: Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.TISSUE SPECIFICITY: Expressed in muscle and lung, less so in liver, brain and kidney.PTM: The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress. INVOLVEMENT IN DISEASE: Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. SEQUENCE SIMILARITIES: Belongs to the caveolin family. View All» Product Name: Anti-Caveolin-1, clone E249, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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