货号：MAB5316

品牌：Merck Millipore

规格：500UL

目录价：￥5062.00

市场价格：￥4302.70

会员价格：￥4049.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Rhodopsin Antibody, clone RET-P1 | MAB5316 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: Reacts with a protein of 39 kDa identified as rhodopsin (opsin). MAB5316 specifically labels the axons and synaptic pedicles of the rods. CELLULAR LOCALIZATION: Cytoplasmic View All» Immunogen: Membrane preparation from adult rat retina. View All» Clone: RET-P1 View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: Immunoblotting: 1 μg/mL Immunocytochemistry Immunohistochemistry (frozen and formalin/paraffin): 1-2 μg/mL. Staining of formalin fixed tissue sections requires boiling the tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 minutes followed by cooling at room temperature for 20 minutes. Optimal working dilutions must be determined by end user. View All» Control: POSITIVE CONTROL: IMR-5 cells, brain or retina. View All» Presentation: Purified immunoglobulin. Liquid in 10 mM PBS, pH 7.4 with 0.2% BSA and 15 mM sodium azide. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 6 months. View All» UniProt Number: P08100 View All» Entrez Gene Number: NM_000539.2 View All» Gene Symbol:
  • RHO

  • rhodopsin

  • Opsin-2

  • OPN2

  • Rhodopsin

  • RP4

  • MGC138311

  • MGC138309
    View All» Alternate Names: Opsin 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Western Blotting
      View All» Entrez Gene Summary: Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. View All» UniProt Summary: FUNCTION: SwissProt: P08100 # Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.SIZE: 348 amino acids; 38893 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Rod shaped photoreceptor cells which mediates vision in dim light.PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.DISEASE: SwissProt: P08100 # Defects in RHO are the cause of retinitis pigmentosa type 4 (RP4) [MIM:180380]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP4 inheritance is autosomal dominant. & Defects in RHO are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. & Defects in RHO are a cause of autosomal dominant congenital stationary night blindness 1 (CSNBAD1) [MIM:610445]; also known as rhodopsin-related congenital stationary night blindness. Congenital stationary night blindness is a nonprogressive retinal disorder characterized by impaired night vision and ocular symptoms such as myopia, hyperopia, nystagmus and reduced visual acuity.SIMILARITY: SwissProt: P08100 ## Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. View All» Brand Family: Chemicon View All» Product Name: Anti-Rhodopsin Antibody, clone RET-P1 | MAB5316 View All» Concentration: 200 μg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 500 µL View All» Format: Purified View All» Host: Mouse View All»
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