货号：MAB5328

品牌：Merck Millipore

规格：100Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RAGE Antibody, clone DD/A11 or A11 | MAB5328 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Specificity: RAGE (Receptor for Advanced Glycosylated End Products). The antibody recognizes both natural and recombinant RAGE. View All» Molecular Weight: 48 kDa View All» Epitope: Extracellular View All» Immunogen: Recombinant truncated extracellular part of RAGE produced in E. coli. View All» Clone: DD/A11 or mAbA11 View All» Isotype: IgG2a View All» Background Information: RAGE (Receptor for Advanced Glycosylation End Products) is a 35 kDa cell surface receptor that binds molecules modified by advanced glycation end products (AGEs), an irreversible non-enzymatic reaction occuring from the interaction of proteins and lipids with glucose. The increased expression of RAGE is associated with many disorders, such as diabetic vasculopathy, neuropathy, retinopathy and neuropathy, Alzheimer’s disease and immune/inflammatory reactions of the vessel walls. AGE/RAGE accumulates at sites of vascular disease in diabetes, but blockade of RAGE suppresses development of atherosclerosis and vascular disorders. RAGE binds to amyloid beta, which is overproduced in neurons and vessels in Alzheimer's disease, and this interaction results in oxidative stress leading to neuronal degeneration. View All» Species Reactivity:

• Bovine

• Human

• Mouse
  View All» Species Reactivity Note: Mouse. Expected to react with rat based on sequence homology. View All» Application Notes: Immunohistochemistry: A previous lot of this antibody was shown to be reactive on paraffin embedded tissue sections.Immunocytochemistry: A previous lot was shown to work on cells fixed with ice cold acetone using a Cy3 conjugated secondary antibody.ELISA: A previous lot was shown to work on direct ELISA. Immunoblotting: Recognizes a band of ~48kDa in bovine lung extract. Optimal working dilutions must be determined by end user. View All» Control: Lung tissue, mouse brain lysate. View All» Quality Assurance: Routinely evaluated by Western Blot on Mouse Brain lysates.Western Blot: 1:500 dilution of this lot detected RAGE on 10 μg of Mouse Brain lysates. View All» Purification Method: Protein A purfied View All» Presentation: Purified mouse monoclonal IgG2a in buffer containing 0.02 M phosphate buffer, 0.25 M NaCl, and 0.1% sodium azide. View All» Storage Conditions: Stable for 6 months at 2-8ºC in undiluted aliquots from date of receipt. View All» UniProt Number: Q15109 View All» Entrez Gene Number: NM_014226.1 View All» Gene Symbol:
  • RAGE

  • RAGE-1

  • MOK

  • RAGE1

  • EC 2.7.11.22
    View All» Alternate Names: Receptor for Advanced Glycosylation End Products. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunocytochemistry

    • Immunohistochemistry

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: Q15109 # Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Receptor for amyloid beta peptide. SIZE: 404 amino acids; 42803 Da SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. TISSUE SPECIFICITY: Endothelial cells.PTM: Autophosphorylated (By similarity).SIMILARITY: SwissProt: Q15109 # Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. View All» Brand Family: Chemicon View All» Product Name: Anti-RAGE Antibody, clone DD/A11 or A11 | MAB5328 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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      © Merck Millipore代理MAB5328 Anti-RAGE Antibody, clone DD/A11 or A11;抗-RAGE抗体，克隆DD/A11或A11store at +2℃ to +8℃，产品报价联系微信jinshanbio