货号：04-578

品牌：Merck Millipore

规格：

目录价：￥4118.00

市场价格：￥3500.30

会员价格：￥3294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Smac/DIABLO Antibody, Rabbit, clone Y12 | 04-578 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Human, Rat Smac/Diablo. View All» Immunogen: A synthetic peptide corresponding to C-terminal residues human Smac/DIABLO. View All» Clone: Y12 View All» Background Information: Smac/DIABLO (Second Mitochondria-derived Activator of Caspases/Direct IAP Binding Protein with Low PI) is localized to the mitochondria and involved in activating programmed cell death, or apoptosis (1). In response to apoptotic stimuli, Smac/DIABLO is released from the mitochondria and binds anti-apoptotic IAP proteins, supressing their inhibitory activity and promoting caspase activation (1,2). This interaction involves primarily the amino-terminal residues of Smac/DIABLO with the BIR3 region of the IAP protein (3,4). View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Human, Rat (positive control: Jurkat cell lysate) View All» Application Notes: WB: 1:1,000 IHC: 1:10 (Paraffin-embedded human skin cancer tissue) ICC: 1:10 Flow Cytometry: 1:10-50 IP: 1:10-80 View All» Presentation: Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Store at -20 °C. Stable for 12 months from date of receipt. View All» UniProt Number: Q9NR28 View All» Entrez Gene Number:
  • NM_019887.3

  • NM_138929.2

  • NM_138930.2
    View All» Gene Symbol:
    • DIABLO

    • SMAC

    • DIABLO-S

    • FLJ25049

    • 0610041G12Rik

    • diablo

    • FLJ10537

    • SMAC3
      View All» Alternate Names: Second Mitochondria-derived Activator of Caspases/Direct IAP Binding Protein with Low PI View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Flow Cytometry

      • Immunoprecipitation

      • Western Blotting

      • Immunocytochemistry

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and it moderates the caspase inhibition of IAPs. Multiple polyadenylation sites have been found for this gene. Several alternatively spliced transcript variants that encode distinct isoforms have been described for this gene but the validity of some transcripts, and their predicted ORFs, has not been determined conclusively. View All» UniProt Summary: FUNCTION: SwissProt: Q9NR28 # Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).SIZE: 239 amino acids; 27131 Da SUBUNIT: Interacts with NGFRAP1/BEX3 (By similarity). Homodimer. Interacts with BIRC2, BIRC3, BIRC4/XIAP and BIRC7.SUBCELLULAR LOCATION: Mitochondrion. Note=But released into the cytosol when cells undergo apoptosis.TISSUE SPECIFICITY: Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.DOMAIN:SwissProt: Q9NR28 The mature N-terminus mediates interaction with BIRC4/XIAP. SIMILARITY: View All» Brand Family: Upstate View All» Product Name: Anti-Smac/DIABLO Antibody, Rabbit, clone Y12 | 04-578 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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