货号：04-580

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MALT1/MLT1 (N-Term) Antibody, clone EP603Y | 04-580 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Human MALT1/MLT1 (N-Term). View All» Immunogen: A synthetic peptide corresponding to residues in the N-term of human MALT1. This antibody is predicted to detect splice isoform 2 based on sequence analysis. View All» Clone: EP603Y View All» Background Information: Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), also known as MLT1 or paracaspase 1, is a member of the human paracaspase family and an interacting partner of B-cell lymphoma 10 (Bcl-10) (1). In vitro, In vitro, MALT1 synergizes with BCL10 to enhance nuclear factor B activation (2) and to mediate IB kinase (IKK) activation by facilitating the ubiquitinylation of the NF-B essential modulator (NEMO) (3). MALT1 is found in recurrent chromosomal translocations in non-Hodgkin B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT). One common translocation juxtaposes the MALT1 gene to the IgH promoter region, resulting in up-regulation of Bcl-10 and MALT1 (4). Another common translocation creates a fusion between MALT1 and the inhibitor of apoptosis gene API2 ( cIAP2/HIAP1) (5). View All» Species Reactivity: Human View All» Species Reactivity Note: Human (positive control: Jurkat cell lysate) View All» Application Notes: WB: 1:2,000 Flow Cytometry: 1:30 IP: 1:50 View All» Presentation: Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Store at -20 °C. Stable for 12 months from date of receipt. View All» UniProt Number: Q9UDY8 View All» Entrez Gene Number:

• NM_006785.2

• NM_173844.1
  View All» Gene Symbol:
  • MALT1

  • paracaspase

  • MLT1

  • MLT

  • Paracaspase

  • DKFZp434L132
    View All» Alternate Names: Mucosa-associated lymphoid tissue lymphoma translocation protein 1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q9UDY8 # Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity.SIZE: 824 amino acids; 92272 Da SUBUNIT: Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6.SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.TISSUE SPECIFICITY: Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.DISEASE: SwissProt: Q9UDY8 # A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.SIMILARITY: SwissProt: Q9UDY8 ## Belongs to the peptidase C14 family. & Contains 1 death domain. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. View All» Brand Family: Upstate View All» Product Name: Anti-MALT1/MLT1 (N-Term) Antibody, clone EP603Y | 04-580 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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