货号：04-583

品牌：Merck Millipore

规格：EA

目录价：￥4288.00

市场价格：￥3644.80

会员价格：￥3430.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PAK4 (N-Term) Antibody | 04-583 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Human, Mouse, Rat PAK4 (N-Term). View All» Immunogen: A synthetic peptide corresponding to residues in the N-terminus of human PAK4. View All» Background Information: p21-activated kinase 4 (PAK4) is a member of a family of serine/threonine protein kinase defined by their interaction with the small GTPases, Cdc42 and Rac (1-2). The PAK proteins can be essentially divided into two categories, groups I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK5 and PAK6), based on their structures (3). PAK4 has been shown to regulate cytoskeletal organization and to protect cells from apoptosis induced by multiple stimuli, including serum withdrawal, tumor necrosis factor- (TNF) treatment, or UV irradiation (4). PAK4 expression is elevated in many cancer cell lines, and activated PAK4 is highly transforming, suggesting an important role in tumorigenesis (5). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, Mouse, Rat (positive control: SH-SY-5Y cell lysate) View All» Application Notes: WB: 1:1000 View All» Purification Method: Protein A purfied View All» Presentation: Buffer: 50 mM Tris-Glycine (pH 7.4), 0.18 M NaCl, 40% Glycerol, 0.25% sodium azide, 0.25 mM EDTA, 25 mM Citric Acid, and 0.5% BSA. View All» Storage Conditions: Store at -20 °C. Stable for 12 months from date of receipt. View All» UniProt Number: O96013 View All» Entrez Gene Number:
  • NM_001014833.1

  • NM_001014831.2

  • NM_001014832.1

  • NM_001014834.2

  • NM_001014835.1

  • NM_005884.3
    View All» Gene Symbol:
    • PAK4

    • PAK-4

    • KIAA1142
      View All» Alternate Names: p21-activated kinase 4 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: O96013 # Activates the JNK pathway. Plays a role in the reorganization of the actin cytoskeleton and in the formation of filopodia. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments.SIZE: 591 amino acids; 64072 Da SUBUNIT: Interacts with FGFR2 and GRB2 (By similarity). Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and weakly with RAC1.TISSUE SPECIFICITY: Highest expression in prostate, testis and colon.PTM: Autophosphorylated on serine residues when activated by CDC42/p21. & Phosphorylated on tyrosine residues upon stimulation of FGFR2 (By similarity).SIMILARITY: SwissProt: O96013 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 CRIB domain. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-PAK4 (N-Term) Antibody | 04-583 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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