货号：04-588

品牌：Merck Millipore

规格：

目录价：￥4224.00

市场价格：￥3590.40

会员价格：￥3379.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytokeratin 8 Antibody, Rabbit, clone E432 | 04-588 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Human, Mouse Cytokeratin 8. View All» Immunogen: A synthetic peptide corresponding to residues surrounding Ser73 of human Cytokeratin 8. View All» Clone: E432 View All» Background Information: Keratin polypeptides 8 and 18 (K8/18) are intermediate filament phosphoglycoproteins that are expressed preferentially in glandular epithelia. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells (1-3). Together with actin microfilaments and microtubules, keratin filaments make up the cytoskeletons of vertebrate epithelial cells, forming alpha-helical coiled-coil dimers which associate laterally and end-to-end to form 10-nm diameter filaments (4). View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human, Mouse (positive control: A431 cell lysate) View All» Application Notes: WB: 1:500 IHC: 1:250-1:500 (Paraffin-embedded stomach carcinoma) ICC: 1:50 Flow Cytometry: 1:20 View All» Purification Method: Protein A purfied View All» Presentation: Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Store at -20 °C. Stable for 12 months from date of receipt. View All» UniProt Number: P05787 View All» Entrez Gene Number: NM_002273.2 View All» Gene Symbol:
  • KRT8

  • Cytokeratin-8

  • Keratin-8

  • K2C8

  • CYK8

  • CK-8

  • KO

  • K8

  • CK8

  • CARD2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry (Paraffin)
      View All» UniProt Summary: FUNCTION: SwissProt: P05787 # Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.SIZE: 483 amino acids; 53704 Da SUBUNIT: Heterotetramer of two type I and two type II keratins. keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization.DISEASE:SwissProt: P05787 # Defects in KRT8 are a cause of cryptogenic cirrhosis [MIM:215600].SIMILARITY: SwissProt: P05787 ## Belongs to the intermediate filament family.MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). View All» Brand Family: Upstate View All» Product Name: Anti-Cytokeratin 8 Antibody, Rabbit, clone E432 | 04-588 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-131957.htm
      © Merck Millipore代理04-588 Anti-Cytokeratin 8, clone E432 (Rabbit Monoclonal)，产品报价联系微信jinshanbio