货号：MAB5364A4

品牌：Merck Millipore

规格：100UL

目录价：￥5732.00

市场价格：￥4872.20

会员价格：￥4585.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Reelin Antibody, clone G10, Alexa Fluor® 488 Conjugate | MAB5364A4 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Molecular Weight: 388 kDa calculated View All» Immunogen: Recombinant protein corresponding to rat Reelin. View All» Isotype: IgG View All» Background Information: Reelin, a glycoprotein, plays a crucial role during embryonic neuronal migration, primarily as a regulator of corticogenesis and neuronal cell positioning in the prenatal period. In adults, reelin may act as a modulator of synaptic plasticity. Reelin has been implicated to play a role in several brain diseases including schizphrenia, Alzheimers's disease, temporal lobe epilespy, and autism. Reelin is found in the brain, spinal cord, blood, and other body organs and tissues. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Mouse and Rat. View All» Application Notes: Immunocytochemistry Analysis: A 1:400 dilution from a representative lot detected Reelin in rat E18 primary cortex cells. View All» Control: Adult mouse brain tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in adult mouse brain tissue.Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Reelin in adult mouse brain tissue. View All» Purification Method: Protein A purified View All» Presentation: Purified mouse monoclonal IgG1 conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA. View All» Storage Conditions: Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. View All» UniProt Number: P58751 View All» Entrez Gene Number: NP_536319 View All» Gene Symbol: Reln View All» Alternate Names: Reelin View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunocytochemistry

  • Immunohistochemistry
    View All» Entrez Gene Summary: This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. View All» UniProt Summary: FUNCTION: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and ApoER2 induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity).SIZE: 3460 amino acids; 388402 Da SUBUNIT: Binds to the ectodomains of VLDLR and ApoER2 (By similarity).SUBCELLULAR LOCATION: Secreted (By similarity).TISSUE SPECIFICITY: Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Also expressed in fetal and adult liver.DEVELOPMENTAL STAGE: Expressed in fetal and postnatal brain and liver. Expression in postnatal human brain is high in the cerebellum.DOMAIN: The basic C-terminal region is essential for secretion (By similarity).DISEASE: Defects in RELN are the cause of autosomal recessive lissencephaly with cerebellar hypoplasia [MIM:257320]; also known as Norman-Roberts syndrome. Some patients also displayed persistent lymphedema neonatally, and one showed accumulation of chlyous or fatty, ascites fluid. & Defects in RELN may contribute to susceptibility to schizophrenia. Expression of the protein is reduced to about 50% in patients with schizophrenia. & Defects in RELN may predispose to autistic disorder. A polymorphic GGC triplet repeat located in the 5'-UTR region of RELN gene, which harbors in the normal population 8 to 10 repeats, is significantly increased in autistic patients to carry 4 to 23 additional repeats.SIMILARITY: Belongs to the reelin family. & Contains 15 BNR repeats. & Contains 8 EGF-like domains. & Contains 1 reelin domain. View All» Product Name: Anti-Reelin, clone G10, Alexa Fluor® 488 Conjugate View All» Qty/Pk: 100 µL View All» Format: AlexaFluor®488 View All» Host: Mouse View All»
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